ARHGAP5 and PTPN18

Number of citations of the paper that reports this interaction (PMID 15588985)
37

Data Source:
HPRD (in vivo)

		ARHGAP5	PTPN18
Gene Name		Rho GTPase activating protein 5	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Nucleus Cytoplasm
	Molecular Function	GTPase Activity Rho GTPase Activator Activity Protein Binding GTP Binding SH2 Domain Binding	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Metabolic Process Regulation Of Cell Size Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of Rho GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ADRB2 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND1 RND2 RND3 SMURF2	9 interactors: ABL1 ARHGAP5 CSK ERBB2 GAB1 PSTPIP1 PSTPIP2 SRC TEC
Entrez ID		394	26469
HPRD ID		04060	05961
Ensembl ID		ENSG00000100852	ENSG00000072135
Uniprot IDs		Q13017	Q99952
PDB IDs		2EE4 2EE5	2OC3 4GFU
Enriched GO Terms of Interacting Partners?		Axon Guidance Neuron Projection Development Regulation Of Cell-substrate Adhesion Cell Junction Assembly Generation Of Neurons Neuron Development Neurogenesis Axonogenesis Positive Regulation Of Neuron Projection Development Signal Transduction Axon Development Cell Morphogenesis Involved In Neuron Differentiation Response To External Stimulus Actin Cytoskeleton Organization Neuron Differentiation Chemotaxis Cell-cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Cell Projection Organization Signaling Positive Regulation Of Cell Projection Organization Neuron Projection Morphogenesis Actin Filament-based Process Cell Communication Locomotion Positive Regulation Of Signal Transduction Cell Morphogenesis Involved In Differentiation Positive Regulation Of Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Positive Regulation Of Cell-substrate Adhesion Nervous System Development Integrin-mediated Signaling Pathway Regulation Of Neuron Projection Development Cell Differentiation Movement Of Cell Or Subcellular Component Negative Regulation Of Anoikis Cell Projection Morphogenesis Cellular Response To Stimulus Cell Part Morphogenesis Positive Regulation Of Neurogenesis Blood Vessel Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Anoikis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Morphogenesis Blood Vessel Endothelial Cell Migration Heterotypic Cell-cell Adhesion Regulation Of Cell Projection Organization Positive Regulation Of Cell Development	Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Innate Immune Response ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Protein Autophosphorylation Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Defense Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Wound Healing Regulation Of MAPK Cascade Immune System Process Regulation Of Immune System Process Positive Regulation Of Protein Serine/threonine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Wounding Regulation Of MAP Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Cell Proliferation Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Response To Organonitrogen Compound Positive Regulation Of Phosphorylation Regulation Of Cell-cell Adhesion Axon Guidance Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Intracellular Signal Transduction Response To Oxidative Stress Central Nervous System Development Organ Development Response To Peptide Hormone Antigen Receptor-mediated Signaling Pathway Phosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of Cell Activation Cellular Response To Organonitrogen Compound
Tagcloud ?		10a 200c 30a 30c cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3	able al authors barcodes barcoding concept dynamic emerging et forms gives modifications nature oncogene paper pest phosphatase proteasomal rather refers regulate relay rise signals throughout trafficking translational ubiquitination wang
Tagcloud (Difference) ?		10a 200c 30a 30c cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3	able al authors barcodes barcoding concept dynamic emerging et forms gives modifications nature oncogene paper pest phosphatase proteasomal rather refers regulate relay rise signals throughout trafficking translational ubiquitination wang
Tagcloud (Intersection) ?