ARHGAP4 and NRAS

Number of citations of the paper that reports this interaction (PMID 10655059)
42

Data Source:
HPRD (in vitro)

		ARHGAP4	NRAS
Gene Name		Rho GTPase activating protein 4	neuroblastoma RAS viral (v-ras) oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Microtubule Focal Adhesion Growth Cone	Golgi Membrane Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Rho GTPase Activator Activity Protein Binding Rac GTPase Activator Activity Rac GTPase Binding	GTP Binding Protein Complex Binding
	Biological Process	Cytoskeleton Organization Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Fibroblast Migration Negative Regulation Of Cell Migration Negative Regulation Of Axon Extension Positive Regulation Of Rac GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	MAPK Cascade Activation Of MAPKK Activity Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Actin Cytoskeleton Organization Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Skeletal Muscle Tissue Development Leukocyte Migration Striated Muscle Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation RAF activation SHC1 events in EGFR signaling IRS-mediated signalling Activation of RAS in B cells FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: MAP3K1 NRAS	19 interactors: ACVR1 ARHGAP4 BCL2 DNAJB1 EEF1A1 PIK3CA PIK3CG PLCE1 RACGAP1 RAF1 RAP1GDS1 RASGRP2 RASSF5 RGL2 RPS20 SHOC2 SMAD4 SMURF2 SRI
Entrez ID		393	4893
HPRD ID		02063	01273
Ensembl ID		ENSG00000089820	ENSG00000213281
Uniprot IDs		F5GZW3 P98171	P01111 Q5U091
PDB IDs		2EPD	3CON
Enriched GO Terms of Interacting Partners?		Activation Of MAPKK Activity Fc-epsilon Receptor Signaling Pathway MAPK Cascade Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Signal Transduction By Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Rac Protein Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Actin Cytoskeleton Organization Regulation Of MAPK Cascade Actin Filament-based Process Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Immune Response Eyelid Development In Camera-type Eye Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Negative Regulation Of Skeletal Muscle Tissue Development Cell Morphogenesis Regulation Of Protein Phosphorylation Epithelium Development Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Synaptic Transmission, GABAergic Immune Response Regulation Of Immune System Process Regulation Of Rac Protein Signal Transduction Regulation Of Phosphorylation Defense Response Activation Of JUN Kinase Activity Regulation Of Phosphorus Metabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis	Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Ras Protein Signal Transduction Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Ras Protein Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Cardiovascular System Development Cellular Response To Organic Substance Regulation Of Growth Regulation Of Cell Growth Response To Organic Substance Endocardial Cell Differentiation Positive Regulation Of Hydrolase Activity Cell Activation Regulation Of Protein Phosphorylation Response To Wounding Cell Proliferation Cellular Metal Ion Homeostasis Positive Regulation Of GTPase Activity Platelet Activation Blood Coagulation Hemostasis Cellular Cation Homeostasis Regulation Of GTPase Activity Cellular Ion Homeostasis Metal Ion Homeostasis Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Peptidyl-serine Phosphorylation BMP Signaling Pathway Stem Cell Development
Tagcloud ?		abcf2 adprtl1 amy2b atp6ap1 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 ngfrap1 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4	12v2 altering atrx banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs ploidy pnet qgp sanger sequenced snvs stretches toolkit
Tagcloud (Difference) ?		abcf2 adprtl1 amy2b atp6ap1 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 ngfrap1 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4	12v2 altering atrx banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs ploidy pnet qgp sanger sequenced snvs stretches toolkit
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