ARL4D and PRKCSH

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARL4D	PRKCSH
Gene Name		ADP-ribosylation factor-like 4D	protein kinase C substrate 80K-H
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Plasma Membrane	Intracellular Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Protein Kinase C Binding Calcium Ion Binding Ion Channel Binding Phosphoprotein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Metabolic Process Protein Secretion	Protein Folding N-glycan Processing Protein N-linked Glycosylation Via Asparagine Intracellular Signal Transduction Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response
Pathways			Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 N-glycan trimming in the ER and Calnexin/Calreticulin cycle Advanced glycosylation endproduct receptor signaling Defective ALG11 causes ALG11-CDG (CDG-1p) Innate Immune System Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Calnexin/calreticulin cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: APP ARL6IP1 CCDC102B CNPY4 DNAJA1 EIF2B1 EML4 EPRS MAPK8IP3 NDRG1 PGAM1 PRKCSH SMAD1 SMAD2 SMURF1 SNRPN TGFBR1 TLE1 TMEM230 UBR1 UNC119	9 interactors: ARL4D CANX GANAB GBA3 GET4 PTPRC RGS2 RPS6 VDR
Entrez ID		379	5589
HPRD ID		02842	03518
Ensembl ID		ENSG00000175906	ENSG00000130175
Uniprot IDs		P49703	K7ELL7 P14314
PDB IDs
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Primary MiRNA Processing Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Stimulus Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Development Response To Stimulus Response To Organic Substance SMAD Protein Complex Assembly Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Renal System Development Negative Regulation Of Signal Transduction Neurogenesis Production Of MiRNAs Involved In Gene Silencing By MiRNA Response To Cholesterol Post-embryonic Development Urogenital System Development Negative Regulation Of Signaling Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Activin Receptor Signaling Pathway Cell Differentiation Gene Silencing By MiRNA Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Signal Transduction Cellular Response To DsRNA Response To Stress Cellular Protein Metabolic Process Posttranscriptional Gene Silencing In Utero Embryonic Development Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Neuron Differentiation Regulation Of Cellular Process Regulation Of Protein Metabolic Process Signaling Regulation Of Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Cellular Response To Growth Factor Stimulus RNA Processing Negative Regulation Of Clathrin-mediated Endocytosis Regulation Of Pentose-phosphate Shunt Cell Communication Nervous System Development	T Cell Differentiation In Thymus T Cell Proliferation Protein N-linked Glycosylation Via Asparagine Vitamin D Receptor Signaling Pathway Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Lymphocyte Proliferation Mononuclear Cell Proliferation Protein N-linked Glycosylation Cellular Localization Leukocyte Proliferation Protein Secretion Positive Regulation Of Vitamin D 24-hydroxylase Activity Bile Acid Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Secretion Establishment Of Protein Localization T Cell Differentiation Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Activation-induced Cell Death Of T Cells Regulation Of Adrenergic Receptor Signaling Pathway Oogenesis Stage Negative Regulation Of T Cell Mediated Cytotoxicity Placenta Development Mammary Gland Branching Involved In Pregnancy Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Cardiac Muscle Contraction Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Glycoside Catabolic Process Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Post-translational Protein Modification Multicellular Organismal Reproductive Process Negative Regulation Of Protein Kinase Activity Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Multicellular Organism Reproduction Protein Insertion Into ER Membrane Negative Regulation Of Kinase Activity Establishment Of Protein Localization To Membrane Chemical Homeostasis Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation T Cell Proliferation Involved In Immune Response Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Relaxation Of Vascular Smooth Muscle Regulation Of Isotype Switching To IgG Isotypes
Tagcloud ?			abolished antisense axial coreceptors deglycosylation dickkopf1 dkk1 endoplasmic erlectin glycan glycoprotein head homology kremen1 krm1 krm2 mannose member morpholino mrh organogenesis proteomic resident reticulum reveals synexpression traffic xenopus xtp3
Tagcloud (Difference) ?			abolished antisense axial coreceptors deglycosylation dickkopf1 dkk1 endoplasmic erlectin glycan glycoprotein head homology kremen1 krm1 krm2 mannose member morpholino mrh organogenesis proteomic resident reticulum reveals synexpression traffic xenopus xtp3
Tagcloud (Intersection) ?