KCNN4 and PRKAG1

Number of citations of the paper that reports this interaction (PMID 19052260)
13

Data Source:
HPRD (in vivo, two hybrid)

		KCNN4	PRKAG1
Gene Name		potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4	protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Basolateral Plasma Membrane Apical Plasma Membrane Neuronal Cell Body Membrane Raft	Nucleus Cytosol Membrane AMP-activated Protein Kinase Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Calmodulin Binding Calcium-activated Potassium Channel Activity Small Conductance Calcium-activated Potassium Channel Activity Protein Phosphatase Binding Intermediate Conductance Calcium-activated Potassium Channel Activity	Protein Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Binding ADP Binding
	Biological Process	Immune System Process Potassium Ion Transport Calcium Ion Transport Cell Volume Homeostasis Defense Response Synaptic Transmission Stabilization Of Membrane Potential Phospholipid Translocation Saliva Secretion Positive Regulation Of Protein Secretion Positive Regulation Of T Cell Receptor Signaling Pathway Potassium Ion Export Potassium Ion Transmembrane Transport	Regulation Of Glycolytic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Spermatogenesis Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Protein Heterooligomerization Membrane Organization
Pathways		Ca2+ activated K+ channels Potassium Channels	Organelle biogenesis and maintenance Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling Translocation of GLUT4 to the plasma membrane IRS-related events mTOR signalling IGF1R signaling cascade Mitochondrial biogenesis IRS-related events triggered by IGF1R Activation of PPARGC1A (PGC-1alpha) by phosphorylation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs		Clotrimazole Quinine Miconazole Halothane
Diseases
GWAS		Breast cancer ( 23535729)
Protein-Protein Interactions		2 interactors: CALM1 PRKAG1	15 interactors: ACACA AP1S3 C1orf94 CBS KCNN4 KEAP1 KRTAP10-3 KRTAP4-2 PAICS PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 TEKT1
Entrez ID		3783	5571
HPRD ID		04130	04118
Ensembl ID		ENSG00000104783	ENSG00000181929
Uniprot IDs		D1MQ08 D1MQ09 O15554	F8W9D1 P54619
PDB IDs			2UV4 2UV5 2UV6 2UV7
Enriched GO Terms of Interacting Partners?		Mitochondrion Organization Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Transferase Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Phosphorylation Detection Of Calcium Ion Regulation Of Protein Kinase Activity Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Kinase Activity Response To Organonitrogen Compound Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Membrane Organization Positive Regulation Of Phosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Cell Cycle Regulation Of Voltage-gated Calcium Channel Activity Response To Hormone Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Protein Phosphorylation Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Glycolytic Process Activation Of Adenylate Cyclase Activity Positive Regulation Of Cellular Protein Metabolic Process Nitric Oxide Metabolic Process Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Positive Regulation Of Phosphatase Activity	Carnitine Shuttle Carnitine Transmembrane Transport Carnitine Transport Fatty Acid Biosynthetic Process Quaternary Ammonium Group Transport Long-chain Fatty Acid Transport Fatty Acid Metabolic Process Ammonium Transmembrane Transport Cell Cycle Arrest Insulin Receptor Signaling Pathway Fatty Acid Transport Ammonium Transport Cellular Response To Insulin Stimulus Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Response To Insulin Lipid Transport Cellular Response To Peptide Hormone Stimulus Organic Acid Metabolic Process Regulation Of Glycolytic Process Lipid Localization Cellular Response To Peptide Monocarboxylic Acid Transport Regulation Of Lipid Biosynthetic Process Energy Reserve Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Mitochondrial Transport Membrane Organization Organic Anion Transport Sterol Biosynthetic Process Negative Regulation Of Cell Cycle Response To Peptide Hormone Small Molecule Metabolic Process Cellular Response To Organonitrogen Compound Response To Peptide Cellular Lipid Metabolic Process Cellular Response To Hormone Stimulus Inorganic Anion Transport Regulation Of Generation Of Precursor Metabolites And Energy Monovalent Inorganic Cation Transport Anion Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Fatty Acid Metabolic Process Regulation Of Lipid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Carboxylic Acid Transport Organic Acid Transport Lipid Metabolic Process Regulation Of Energy Homeostasis
Tagcloud ?		blockers blocking cns contributes contributions counteract damaged ganglion greatly highlights ik1 instance jak3 kca3 mek microglia microglial migratory neurotoxicity optic p2y2 phosphatidylinositol pursuing rescued rodent sk4 stat6 surprisingly tram
Tagcloud (Difference) ?		blockers blocking cns contributes contributions counteract damaged ganglion greatly highlights ik1 instance jak3 kca3 mek microglia microglial migratory neurotoxicity optic p2y2 phosphatidylinositol pursuing rescued rodent sk4 stat6 surprisingly tram
Tagcloud (Intersection) ?