KCNJ4 and CASK

Number of citations of the paper that reports this interaction (PMID 14960569)
32

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		KCNJ4	CASK
Gene Name		potassium channel, inwardly rectifying subfamily J, member 4	calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Basolateral Plasma Membrane Cell Junction Cytoplasmic Vesicle Membrane Postsynaptic Membrane	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Basolateral Plasma Membrane Nuclear Matrix Presynaptic Membrane Ciliary Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding PDZ Domain Binding	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Neurexin Family Protein Binding
	Biological Process	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Ion Transmembrane Transport	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Negative Regulation Of Keratinocyte Proliferation Extracellular Matrix Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide Phosphorylation Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus
Pathways		GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses	Syndecan interactions Nephrin interactions Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CASK DLG1 DLG2 DLG4 GNGT2 IL16 KCNJ2 LIN7B PRKCD SNTA1	60 interactors: APBA1 ATP2B4 BNIP3L C16orf70 CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DFNB31 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBB2IP F11R FCHSD2 GCNT3 GLS2 GRIK2 GRIN2A HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 LIN7A LIN7B MARS MLLT6 NPHS1 NRXN1 NRXN2 NRXN3 P2RX7 PARK2 PCBP2 PCM1 PLK2 PRKD2 PTGS2 RAB3A RPH3A SDC1 SDC2 SDC3 SDC4 SH2D4A SMEK1 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WNT7B
Entrez ID		3761	8573
HPRD ID		02738	02164
Ensembl ID		ENSG00000168135	ENSG00000147044
Uniprot IDs		P48050 Q58F07	O14936
PDB IDs		3GJ9	1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Regulation Of Ion Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Ion Transmembrane Transport Cell-cell Signaling Positive Regulation Of Ion Transport Receptor Clustering Synaptic Transmission Maintenance Of Apical/basal Cell Polarity Regulation Of Membrane Potential Maintenance Of Cell Polarity Protein Localization To Membrane Regulation Of Actin Filament-based Process Response To External Stimulus Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Membrane Repolarization Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cortical Cytoskeleton Organization Negative Regulation Of Cell Adhesion Nucleobase-containing Small Molecule Metabolic Process Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Muscle System Process Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Transport Membrane Organization Regulation Of Potassium Ion Transport Negative Regulation Of Wound Healing Regulation Of Sodium Ion Transport Positive Regulation Of Phospholipid Scramblase Activity Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Ion Transmembrane Transport Phosphorylation Organophosphate Metabolic Process Regulation Of Striated Muscle Contraction Action Potential Protein Stabilization Negative Regulation Of Homotypic Cell-cell Adhesion Relaxation Of Skeletal Muscle	Synaptic Transmission Signaling Cell Communication Cell-cell Signaling Regulation Of Neurotransmitter Levels Learning Vocalization Behavior Neurotransmitter Secretion Neurotransmitter Transport Single-organism Behavior Learning Or Memory Behavior Cognition Establishment Or Maintenance Of Apical/basal Cell Polarity Cellular Protein Localization Cellular Localization Response To External Stimulus Anatomical Structure Development Social Behavior Cellular Component Assembly Regulation Of Synaptic Transmission System Development Regulation Of Cellular Component Organization Response To Stimulus Synapse Organization Regulation Of Grooming Behavior Regulation Of Organelle Organization Protein Localization To Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Response To Abiotic Stimulus Multicellular Organismal Development Regulation Of Ion Transport Protein Localization Secretion By Cell Membrane Depolarization Developmental Process Anatomical Structure Morphogenesis Neurological System Process Maintenance Of Apical/basal Cell Polarity Cell Adhesion Membrane Organization Receptor Localization To Synapse Regulation Of Cellular Localization Synapse Assembly Regulation Of Signaling Positive Regulation Of Transport Angiogenesis Regulation Of Intracellular Signal Transduction Secretion Positive Regulation Of Exosomal Secretion
Tagcloud ?			channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo
Tagcloud (Difference) ?			channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo
Tagcloud (Intersection) ?