KCNJ3 and GNB1

Number of citations of the paper that reports this interaction (PMID 9108307)
30

Data Source:
HPRD (in vitro, in vivo)

		KCNJ3	GNB1
Gene Name		potassium channel, inwardly rectifying subfamily J, member 3	guanine nucleotide binding protein (G protein), beta polypeptide 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex External Side Of Plasma Membrane T-tubule	Photoreceptor Inner Segment Intracellular Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Vesicle Photoreceptor Outer Segment Membrane Cell Body Extracellular Vesicular Exosome Photoreceptor Disc Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity	GTPase Activity Signal Transducer Activity Protein Binding Spectrin Binding Type 1 Angiotensin Receptor Binding Protein Complex Binding GTPase Binding
	Biological Process	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Ion Transmembrane Transport Response To Electrical Stimulus	Energy Reserve Metabolic Process Signal Transduction Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration G-protein Coupled Acetylcholine Receptor Signaling Pathway Ras Protein Signal Transduction Synaptic Transmission Blood Coagulation Phototransduction, Visible Light Cell Proliferation Cardiac Muscle Cell Apoptotic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Small Molecule Metabolic Process Sensory Perception Of Taste Retina Development In Camera-type Eye Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Cellular Response To Catecholamine Stimulus
Pathways		GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Olfactory Signaling Pathway Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Diseases associated with visual transduction Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G beta:gamma signalling through PI3Kgamma The phototransduction cascade G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Visual phototransduction Ca2+ pathway G-protein activation
Drugs		Halothane
Diseases
GWAS
Protein-Protein Interactions		4 interactors: GNB1 KCNJ5 KCNJ6 KCNJ9	43 interactors: ADRA2A ADRB2 ADRBK1 AFP ARHGEF18 ARRB1 ATXN10 AVPR2 CACNA1A CACNA1B CACNA1C CYFIP1 DISC1 EPHA7 GNA12 GNAS GNB2L1 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 HDAC4 HDAC5 KCNJ3 MCF2 MRGPRX1 MTNR1A MTNR1B NOL11 NR3C1 PDCL PLEKHG2 PTH1R RASD1 RASD2 TBXA2R
Entrez ID		3760	2782
HPRD ID		03323	00766
Ensembl ID		ENSG00000162989	ENSG00000078369
Uniprot IDs		D2X9V0 D2XBF0 P48549	P62873
PDB IDs			4KFM
Enriched GO Terms of Interacting Partners?		Potassium Ion Import Synaptic Transmission Potassium Ion Transmembrane Transport Cell-cell Signaling Potassium Ion Transport Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Monovalent Inorganic Cation Transport Metal Ion Transport Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Transmembrane Transport Ion Transport Cellular Response To Prostaglandin E Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Signaling Cell Communication Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Catecholamine Stimulus Rhodopsin Mediated Signaling Pathway Dopamine Receptor Signaling Pathway Cellular Response To Glucagon Stimulus Cellular Response To Fatty Acid Response To Glucagon Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Sensory Perception Of Taste Response To Fatty Acid Phototransduction, Visible Light Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Detection Of Light Stimulus Cellular Response To Oxygen Levels	Cellular Response To Glucagon Stimulus Signaling Cell Communication Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Glucagon Signal Transduction Cell Surface Receptor Signaling Pathway Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Stimulus Response To Stimulus Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Synaptic Transmission Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cellular Process Response To Peptide Hormone Cell-cell Signaling Cellular Response To Organonitrogen Compound Response To Hormone Cellular Response To Organic Substance Response To Organic Substance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organonitrogen Compound Regulation Of Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Signal Transduction Regulation Of Cyclase Activity Oxidation-reduction Process Regulation Of Muscle Contraction Positive Regulation Of Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Multicellular Organismal Response To Stress Regulation Of CAMP Biosynthetic Process Platelet Activation Regulation Of Insulin Secretion Chemical Homeostasis Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Peptide Hormone Secretion Cellular Process Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Vasoconstriction Small Molecule Metabolic Process
Tagcloud ?		channel classes custom excitability gated genotyping gmm haplotype intriguing inwardly kcna1 kcnd2 kcnj6 kcnk9 latent member membership mild monthly pain persistent postsurgical potassium rectifying snps subfamily variations voltage warrant	abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb2 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants
Tagcloud (Difference) ?		channel classes custom excitability gated genotyping gmm haplotype intriguing inwardly kcna1 kcnd2 kcnj6 kcnk9 latent member membership mild monthly pain persistent postsurgical potassium rectifying snps subfamily variations voltage warrant	abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb2 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants
Tagcloud (Intersection) ?