ITGB7 and ITGA4

Number of citations of the paper that reports this interaction (PMID 14681217)
29

Data Source:
HPRD (in vivo)

		ITGB7	ITGA4
Gene Name		integrin, beta 7	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface Membrane Integrin Alpha4-beta7 Complex Receptor Complex Extracellular Vesicular Exosome	Plasma Membrane Cell-cell Junction Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha4-beta7 Complex Extracellular Vesicular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	Fibronectin Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Multicellular Organismal Development Response To Virus Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Regulation Of Immune Response Leukocyte Tethering Or Rolling T Cell Migration	Blood Vessel Remodeling Cell-matrix Adhesion Involved In Ameboidal Cell Migration Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heart Development Blood Coagulation B Cell Differentiation Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Face Development Chorio-allantoic Fusion T Cell Migration Negative Regulation Of Protein Homodimerization Activity
Pathways		Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System
Drugs			Natalizumab Tinzaparin
Diseases
GWAS		Obesity-related traits ( 23251661)	Celiac disease ( 20190752) Monocyte count ( 23314186) White blood cell count ( 21738480) White blood cell types ( 21738478)
Protein-Protein Interactions		15 interactors: CDH1 DAB1 DOK1 EED FLNA FN1 GNB2L1 ITGA4 ITGAE MADCAM1 PRKCB PRKCD TLN1 TNS2 VCAM1	16 interactors: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN
Entrez ID		3695	3676
HPRD ID		00948	01894
Ensembl ID		ENSG00000139626	ENSG00000115232
Uniprot IDs		P26010	P13612
PDB IDs		2BRQ 3V4P 3V4V	3V4P 3V4V 4HKC
Enriched GO Terms of Interacting Partners?		Cell Adhesion Regulation Of Body Fluid Levels Extracellular Matrix Organization Extracellular Structure Organization Leukocyte Tethering Or Rolling Cell Activation Platelet Activation Blood Coagulation Hemostasis Single Organismal Cell-cell Adhesion Cellular Extravasation Wound Healing Positive Regulation Of Cellular Protein Metabolic Process B Cell Activation Response To Wounding Cell-matrix Adhesion Positive Regulation Of Protein Metabolic Process Receptor Clustering Cell Junction Assembly Cell-substrate Adhesion Regulation Of Immune Response Leukocyte Migration Positive Regulation Of Protein Modification Process Platelet Degranulation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Chorio-allantoic Fusion Regulation Of Protein Metabolic Process Signal Transduction Regulation Of Cellular Process Anatomical Structure Morphogenesis Cellular Response To Stimulus Response To Stimulus Developmental Process Cell Differentiation Cell Morphogenesis Involved In Differentiation Integrin-mediated Signaling Pathway Protein Localization To Membrane Signaling Locomotion Cell Communication Regulation Of Immune System Process Regulation Of Cellular Protein Metabolic Process Labyrinthine Layer Morphogenesis Heterotypic Cell-cell Adhesion Lymphocyte Activation Multicellular Organismal Development Cell Migration Membrane Organization Embryonic Placenta Morphogenesis	Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Leukocyte Tethering Or Rolling Cell-substrate Adhesion Leukocyte Migration Heterotypic Cell-cell Adhesion Regulation Of Immune System Process Integrin-mediated Signaling Pathway Cellular Extravasation Formation Of Primary Germ Layer Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Viral Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Entry Into Host Cell Positive Regulation Of Protein Metabolic Process Gastrulation Locomotion Cell Junction Assembly Cell Differentiation Cell Migration Cell Motility Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Mesoderm Formation Activation Of Protein Kinase Activity Mesoderm Morphogenesis Embryonic Morphogenesis Tissue Morphogenesis Interaction With Host Tissue Development Activation Of Protein Kinase A Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Mesoderm Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Blood Coagulation Hemostasis Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Cardiovascular System Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Anatomical Structure Development ERBB Signaling Pathway Renal Water Homeostasis
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