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ITGA5 and FN1
Number of citations of the paper that reports this interaction (PMID
1694173
)
45
Data Source:
HPRD
(in vivo, in vitro)
ITGA5
FN1
Gene Name
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
fibronectin 1
Image
Gene Ontology Annotations
Cellular Component
Ruffle
Cytoplasm
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Ruffle Membrane
Synapse
Alphav-beta3 Integrin-vitronectin Complex
Extracellular Region
Fibrinogen Complex
Basal Lamina
Extracellular Space
Endoplasmic Reticulum-Golgi Intermediate Compartment
Apical Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Vesicular Exosome
Blood Microparticle
Molecular Function
Epidermal Growth Factor Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
Vascular Endothelial Growth Factor Receptor 2 Binding
Metal Ion Binding
Protease Binding
Integrin Binding
Protein Binding
Collagen Binding
Heparin Binding
Peptidase Activator Activity
Biological Process
Angiogenesis
Cell-substrate Junction Assembly
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Integrin-mediated Signaling Pathway
Axon Guidance
Blood Coagulation
Memory
Positive Regulation Of Cell-substrate Adhesion
Viral Process
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Wound Healing, Spreading Of Epidermal Cells
Endodermal Cell Differentiation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Negative Regulation Of Anoikis
Angiogenesis
Platelet Degranulation
Acute-phase Response
Cell-substrate Junction Assembly
Cell Adhesion
Calcium-independent Cell-matrix Adhesion
Blood Coagulation
Regulation Of Cell Shape
Response To Wounding
Positive Regulation Of Peptidase Activity
Peptide Cross-linking
Extracellular Matrix Disassembly
Platelet Activation
Extracellular Matrix Organization
Integrin Activation
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Positive Regulation Of Axon Extension
Leukocyte Migration
Pathways
Signal transduction by L1
Axon guidance
Elastic fibre formation
Fibronectin matrix formation
L1CAM interactions
Integrin cell surface interactions
Cell surface interactions at the vascular wall
Elastic fibre formation
p130Cas linkage to MAPK signaling for integrins
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
Non-integrin membrane-ECM interactions
Platelet degranulation
Platelet Aggregation (Plug Formation)
Degradation of the extracellular matrix
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Syndecan interactions
ECM proteoglycans
Fibronectin matrix formation
Response to elevated platelet cytosolic Ca2+
Integrin cell surface interactions
Platelet activation, signaling and aggregation
Drugs
Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions
24 interactors:
ANGPT1
ANGPTL3
ARHGAP5
AUP1
CD9
COL18A1
COL1A1
EGFR
ERBB2
FGFR2
FLT4
FN1
GIPC1
GRK6
ITGB1
ITGB3
ITGB5
L1CAM
NISCH
PECAM1
RABIF
SPP1
STAMBP
TNC
96 interactors:
ADAMTS4
AMBP
APCS
ATXN10
ATXN7
C1QA
CD44
CDKN2A
COL13A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A2
COL7A1
COMP
CRP
CTSD
CXCL12
DCN
DUSP10
EGFR
F13A1
FAM86B3P
FASLG
FBLN1
FBLN2
FST
FSTL3
GALNT6
GRB2
GSN
HGF
HRG
HSPG2
IGFBP3
IGFBP5
ITGA3
ITGA4
ITGA5
ITGA8
ITGB1
ITGB3
ITGB6
ITGB7
KLK3
KPNA2
LACRT
LGALS3BP
LPA
LRG1
LTBP1
MAG
MATN2
MEP1A
MEP1B
MIA
MMP9
MYOC
NOV
NR0B2
NT5E
PELI2
PKD1
PLAT
PLG
PRELP
PRPF40A
RARA
RBL1
REG3A
RPS6KA5
SCGB1A1
SDC2
SKIL
SMAD4
SMAD9
SPARC
STAT5A
TAB1
TAB2
TAC1
TGFBI
TGM2
THBS1
TMPRSS6
TNC
TNFRSF11B
TSHR
UBQLN1
VHL
Entrez ID
3678
2335
HPRD ID
00627
00626
Ensembl ID
ENSG00000161638
ENSG00000115414
Uniprot IDs
P08648
P02751
Q6MZF4
Q6MZM7
Q6N084
Q9UQS6
PDB IDs
3VI3
3VI4
1E88
1E8B
1FBR
1FNA
1FNF
1FNH
1J8K
1O9A
1OWW
1Q38
1QGB
1QO6
1TTF
1TTG
2CG6
2CG7
2CK2
2CKU
2EC3
2FN2
2FNB
2GEE
2H41
2H45
2HA1
2OCF
2RKY
2RKZ
2RL0
3CAL
3EJH
3GXE
3M7P
3MQL
3R8Q
3T1W
3ZRZ
4GH7
4JE4
4JEG
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Cell Adhesion
Positive Regulation Of Cellular Component Movement
Positive Regulation Of Locomotion
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of Cell Migration
Regulation Of Cell Motility
Cardiovascular System Development
Regulation Of Locomotion
Regulation Of Cellular Component Movement
Blood Vessel Development
Vasculature Development
Leukocyte Migration
Response To Stimulus
Positive Regulation Of Cell Proliferation
Wound Healing
Regulation Of Cell Proliferation
Anatomical Structure Morphogenesis
Response To Wounding
Cell-substrate Adhesion
Cell Migration
Response To Growth Factor
Movement Of Cell Or Subcellular Component
Multicellular Organismal Development
Blood Vessel Morphogenesis
Blood Coagulation
Cell Motility
Hemostasis
System Development
Anatomical Structure Development
Cellular Response To Stimulus
Locomotion
Cell Communication
Positive Regulation Of Signal Transduction
Regulation Of Signaling
Cell-matrix Adhesion
Angiogenesis
Anatomical Structure Formation Involved In Morphogenesis
Regulation Of Signal Transduction
Developmental Process
Response To Vitamin
Response To Nutrient
Regulation Of Body Fluid Levels
Signaling
Cell Activation
Regulation Of Cellular Process
Formation Of Primary Germ Layer
Signal Transduction
Extracellular Matrix Organization
Extracellular Structure Organization
Extracellular Matrix Disassembly
Developmental Process
Multicellular Organismal Development
Anatomical Structure Morphogenesis
System Development
Anatomical Structure Development
Collagen Catabolic Process
Response To Stimulus
Response To External Stimulus
Collagen Metabolic Process
Multicellular Organismal Macromolecule Metabolic Process
Locomotion
Multicellular Organismal Metabolic Process
Cell Differentiation
Wound Healing
Tissue Development
Response To Wounding
Axon Guidance
Response To Growth Factor
Response To Organic Substance
Organ Development
Response To Stress
Cellular Response To Stimulus
Cell Morphogenesis Involved In Differentiation
Movement Of Cell Or Subcellular Component
Neurogenesis
Generation Of Neurons
Chemotaxis
Regulation Of Cell Adhesion
Cell Adhesion
Axon Development
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Axonogenesis
Cell Projection Organization
Cell Morphogenesis
Cardiovascular System Development
Nervous System Development
Neuron Projection Development
Skeletal System Development
Cell Morphogenesis Involved In Neuron Differentiation
Anatomical Structure Formation Involved In Morphogenesis
Neuron Development
Regulation Of Locomotion
Organ Morphogenesis
Cell Communication
Neuron Projection Morphogenesis
Tagcloud
?
2q33
2q34
artificial
bcg
brazilian
exon
il8
il8r
il8ra
il8rb
ity
leishmaniasis
leprosy
linkage
lod
lsh
nramp
pedigrees
proline
pseudogene
q35
q37
segregating
sh3
synteny
tnp1
typed
vil1
visceral
Tagcloud (Difference)
?
2q33
2q34
artificial
bcg
brazilian
exon
il8
il8r
il8ra
il8rb
ity
leishmaniasis
leprosy
linkage
lod
lsh
nramp
pedigrees
proline
pseudogene
q35
q37
segregating
sh3
synteny
tnp1
typed
vil1
visceral
Tagcloud (Intersection)
?