IRF7 and TRMT61B

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		IRF7	TRMT61B
Gene Name		interferon regulatory factor 7	tRNA methyltransferase 61B
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane	Mitochondrion TRNA (m1A) Methyltransferase Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity DNA Binding Protein Binding	Protein Binding TRNA (adenine-N1-)-methyltransferase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Adaptive Immune Response Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Response To Virus Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Cytokine-mediated Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-alpha Production Interferon-beta Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Type I Interferon Biosynthetic Process Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	Protein Homooligomerization Mitochondrial TRNA Methylation
Pathways		TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Toll Like Receptor 7/8 (TLR7/8) Cascade Interferon Signaling Cytokine Signaling in Immune system Factors involved in megakaryocyte development and platelet production MyD88-independent cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling Activated TLR4 signalling TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated IRF7 activation Interferon alpha/beta signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Toll Like Receptor 9 (TLR9) Cascade Innate Immune System
Drugs
Diseases
GWAS		Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		25 interactors: ACADS AIP ARAF CCDC47 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B	3 interactors: FAM9B IRF7 PPP2CB
Entrez ID		3665	55006
HPRD ID		05441	07935
Ensembl ID		ENSG00000185507	ENSG00000171103
Uniprot IDs		M9RSF4 Q92985	Q9BVS5
PDB IDs		2O61	2B25
Enriched GO Terms of Interacting Partners?		Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Immune Response Response To Biotic Stimulus Regulation Of Cytokine Production Viral Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of Interferon-beta Production Cellular Response To Lipopolysaccharide Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Molecule Of Bacterial Origin Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Response To Bacterium Defense Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stimulus Regulation Of Interferon-beta Production Lipopolysaccharide-mediated Signaling Pathway Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Chemokine Production	Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Interferon-beta Production Interferon-alpha Production Negative Regulation Of Macrophage Apoptotic Process Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Establishment Of Viral Latency Type I Interferon Biosynthetic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Monocyte Differentiation Type I Interferon Production Cellular Response To Virus Regulation Of Macrophage Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Interferon-alpha Production Cytokine Biosynthetic Process Positive Regulation Of Interferon-beta Production Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cytokine Metabolic Process Regulation Of Myeloid Cell Apoptotic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Interferon-beta Production Cellular Response To Stress Negative Regulation Of Leukocyte Apoptotic Process Response To Antibiotic Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Apoptotic Mitochondrial Changes Cellular Response To Organic Substance Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Response To Type I Interferon Regulation Of Myeloid Leukocyte Differentiation Interferon-gamma-mediated Signaling Pathway Response To Hydrogen Peroxide Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cytokine Production
Tagcloud ?		abolished activator amlexanox aortic augment augmentation augmented end endothelial epsilon gamma ifn ikappab ikk inducible interferon jak janus murine nitric oxide poly production stat synthase tank tbk transducer	apoeepsilon4 astrocyte astrocytes billion c3 capture carriers cd74 cingulate clarified clu coexpression contributions decades deficits differentially fastkd2 measureable microdissected ndufa4l2 pc posterior precuneus publicly reads resource storage transcriptome weighted
Tagcloud (Difference) ?		abolished activator amlexanox aortic augment augmentation augmented end endothelial epsilon gamma ifn ikappab ikk inducible interferon jak janus murine nitric oxide poly production stat synthase tank tbk transducer	apoeepsilon4 astrocyte astrocytes billion c3 capture carriers cd74 cingulate clarified clu coexpression contributions decades deficits differentially fastkd2 measureable microdissected ndufa4l2 pc posterior precuneus publicly reads resource storage transcriptome weighted
Tagcloud (Intersection) ?