CXCL10 and IGFBP7

Number of citations of the paper that reports this interaction (PMID 12847218)
6

Data Source:
HPRD (in vivo)

		CXCL10	IGFBP7
Gene Name		chemokine (C-X-C motif) ligand 10	insulin-like growth factor binding protein 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Protein Binding Chemokine Activity Heparin Binding CAMP-dependent Protein Kinase Regulator Activity CXCR3 Chemokine Receptor Binding	Protein Binding Insulin-like Growth Factor Binding
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Muscle Organ Development Blood Circulation Positive Regulation Of Cell Proliferation Protein Secretion Response To Cold Response To Gamma Radiation T Cell Chemotaxis Response To Auditory Stimulus Negative Regulation Of Angiogenesis Positive Regulation Of CAMP Metabolic Process Response To Vitamin D Cellular Response To Heat Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Myoblast Differentiation Regulation Of Protein Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Myoblast Fusion Positive Regulation Of T Cell Migration	Regulation Of Cell Growth Cell Adhesion Embryo Implantation Negative Regulation Of Cell Proliferation Response To Heat Response To Retinoic Acid Cellular Response To Hormone Stimulus Inner Ear Development Regulation Of Steroid Biosynthetic Process Response To Cortisol
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs		N-Methylleucine
Diseases
GWAS			Age-related macular degeneration ( 21909106)
Protein-Protein Interactions		5 interactors: CCR3 CXCR3 DPP4 IGFBP7 VCAN	11 interactors: CCL21 CCL5 CHMP3 CXCL10 IGF1 IGF2 INHBA INS RBBP8 SDC1 VEGFA
Entrez ID		3627	3490
HPRD ID		00930	04183
Ensembl ID		ENSG00000169245	ENSG00000163453
Uniprot IDs		P02778	Q16270
PDB IDs		1LV9 1O7Y 1O7Z 1O80
Enriched GO Terms of Interacting Partners?		Cell Adhesion Locomotion Chemokine-mediated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Endothelial Cell Proliferation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Proliferation Chemokine (C-C Motif) Ligand 11 Production Cell Migration Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Motility Cytosolic Calcium Ion Homeostasis Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Regulation Of Angiogenesis Response To Cortisol Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Chemotaxis Response To Stress Chemokine Production Dermatan Sulfate Biosynthetic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Execution Phase Of Apoptosis Dermatan Sulfate Proteoglycan Biosynthetic Process Cellular Metal Ion Homeostasis Dermatan Sulfate Proteoglycan Metabolic Process Positive Regulation Of CAMP-mediated Signaling Chondroitin Sulfate Catabolic Process Inflammatory Response Cellular Cation Homeostasis Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Lymphocyte Chemotaxis Metal Ion Homeostasis T Cell Migration Cellular Response To Organic Substance Regulation Of CAMP-mediated Signaling Chondroitin Sulfate Biosynthetic Process Cellular Chemical Homeostasis Regulation Of Execution Phase Of Apoptosis Ion Homeostasis Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Cytokine Stimulus Chemotaxis Lymphocyte Migration	Positive Regulation Of Transport Positive Regulation Of Protein Kinase B Signaling Regulation Of Protein Kinase B Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Behavior Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Secretion By Cell Response To Stress Positive Regulation Of Leukocyte Migration Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of T Cell Migration Regulation Of Cellular Localization Regulation Of T Cell Migration Regulation Of Cell Migration Leukocyte Chemotaxis Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Chemotaxis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Secretion Regulation Of Leukocyte Migration Positive Regulation Of Cell Division Regulation Of Locomotion Cell Activation Positive Regulation Of Behavior Regulation Of Cellular Component Movement Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Chemotaxis
Tagcloud ?		a1 adds allocation apolipoprotein beyond biomarkers composite counting deviation ever fourth immunoassay incident individually kallikrein longitudinal metalloproteinase mi multivariable net norway platform reclassification roc stepwise thrombospondin traditional tromso utilizes	achieve additive aza dc demethylating demethylation deoxycytidine difficult dual efficiently epigenetic exists ezh2 focusing gsk126 h3k27me3 limitation methylated methylation modification modifications overcome preferentially promising re sfrp1 trimethylation utilized xenograft
Tagcloud (Difference) ?		a1 adds allocation apolipoprotein beyond biomarkers composite counting deviation ever fourth immunoassay incident individually kallikrein longitudinal metalloproteinase mi multivariable net norway platform reclassification roc stepwise thrombospondin traditional tromso utilizes	achieve additive aza dc demethylating demethylation deoxycytidine difficult dual efficiently epigenetic exists ezh2 focusing gsk126 h3k27me3 limitation methylated methylation modification modifications overcome preferentially promising re sfrp1 trimethylation utilized xenograft
Tagcloud (Intersection) ?