CXCR2 and MYO5B

Number of citations of the paper that reports this interaction (PMID 15004234)
40

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CXCR2	MYO5B
Gene Name		chemokine (C-X-C motif) receptor 2	myosin VB
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Mast Cell Granule	Myosin Complex Cytoplasmic Vesicle Membrane Protein Complex Apical Cortex Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Interleukin-8 Receptor Activity Protein Binding C-X-C Chemokine Receptor Activity Interleukin-8 Binding	Microfilament Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Rab GTPase Binding
	Biological Process	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis	Renal Water Homeostasis Water Transport Metabolic Process Protein Transport Vesicle-mediated Transport Endosome Localization Transmembrane Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Vasopressin regulates renal water homeostasis via Aquaporins Aquaporin-mediated transport
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Smooth-surface caries ( 23470693)
Protein-Protein Interactions		21 interactors: ADRA1A ARRB1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 ST13	14 interactors: AMOTL2 BNIP2 COIL CXCR2 KIAA1549 POLR1C RAB11A RAB11B RAB11FIP2 RAB25 RAB8A SMAD3 TCF4 TRIM54
Entrez ID		3579	4645
HPRD ID		00907	07582
Ensembl ID		ENSG00000180871	ENSG00000167306
Uniprot IDs		P25025 Q53PC4	Q7Z7A5 Q9H6Y6 Q9ULV0
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Regulation Of Behavior Inflammatory Response Cytokine-mediated Signaling Pathway Signaling Cell Communication Response To Lipopolysaccharide Receptor Metabolic Process Positive Regulation Of Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Platelet Activation Positive Regulation Of Locomotion Signal Transduction Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Chemotaxis Cellular Response To Stimulus Receptor Internalization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Cytokine Response To External Stimulus Response To Bacterium G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Migration Regulation Of Cell Migration Cell Motility Regulation Of Cell Motility Response To Stress Regulation Of Locomotion Cell Activation Blood Coagulation Cellular Response To Organic Substance Regulation Of Cellular Component Movement Hemostasis Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Other Organism Response To Stimulus Regulation Of Cell Proliferation Response To Biotic Stimulus	Rab Protein Signal Transduction Vesicle Localization Exocytosis Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Organelle Localization Insulin Secretion Involved In Cellular Response To Glucose Stimulus Establishment Of Vesicle Localization Secretion By Cell Cellular Pigmentation Ras Protein Signal Transduction Secretion Positive Regulation Of Cell Migration Establishment Of Organelle Localization Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Signaling Pigmentation Regulation Of Protein Localization Regulation Of Vesicle-mediated Transport Cell Communication Protein Transport Protein Secretion Vesicle-mediated Transport Response To Glucose Establishment Of Protein Localization Chemical Homeostasis Intracellular Protein Transport Positive Regulation Of Cell Morphogenesis Involved In Differentiation Response To Stimulus Positive Regulation Of Cell Development Renal Water Homeostasis Response To Carbohydrate Cellular Response To Stimulus Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Epithelial To Mesenchymal Transition Glucose Homeostasis Signal Transduction Intracellular Signal Transduction Regulation Of Cell Migration DNA-templated Transcription, Initiation Protein Localization Small GTPase Mediated Signal Transduction Regulation Of Protein Transport Regulation Of Cell Motility Insulin Secretion Water Transport
Tagcloud ?		ab attenuating chemokine chemokines chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic	alleles comprising disequilibrium dyslexia english enrichment explores german germany hereditary language linkage loci minor nedd4l nominal reading relevance replicated rs12606138 rs555879 rs8094327 scerri sets snp snps speaking spelling substantiate
Tagcloud (Difference) ?		ab attenuating chemokine chemokines chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic	alleles comprising disequilibrium dyslexia english enrichment explores german germany hereditary language linkage loci minor nedd4l nominal reading relevance replicated rs12606138 rs555879 rs8094327 scerri sets snp snps speaking spelling substantiate
Tagcloud (Intersection) ?