IL4 and CD53

Number of citations of the paper that reports this interaction (PMID 7963560)
5

Data Source:
HPRD (in vivo)

		IL4	CD53
Gene Name		interleukin 4	CD53 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space External Side Of Plasma Membrane	Immunological Synapse Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity	Protein Binding
	Biological Process	Microglial Cell Activation Innate Immune Response In Mucosa Positive Regulation Of Defense Response To Virus By Host T-helper 1 Cell Lineage Commitment Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Chronic Inflammatory Response Chemotaxis Immune Response Cellular Defense Response Female Pregnancy Response To Nutrient Cholesterol Metabolic Process Regulation Of Proton Transport Response To Organic Cyclic Compound B Cell Differentiation Positive Regulation Of B Cell Proliferation B Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Response To Cytokine T-helper 2 Cell Cytokine Production Type 2 Immune Response Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation B Cell Activation Regulation Of Phosphorylation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Defense Response To Protozoan Negative Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process T-helper 2 Cell Differentiation Positive Regulation Of Chemokine Biosynthetic Process Connective Tissue Growth Factor Biosynthetic Process Regulation Of Isotype Switching Positive Regulation Of MHC Class II Biosynthetic Process Response To Ethanol Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Retina Development In Camera-type Eye Cellular Response To Mercury Ion Positive Regulation Of Mononuclear Cell Migration Dendritic Cell Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Eosinophil Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Signal Transduction Positive Regulation Of Myoblast Fusion
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Cytomegalovirus antibody response ( 21993531) Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: A2M CD53 IL13 IL13RA2 IL2RG IL4R PIK3CD	6 interactors: CD2 CD4 CD9 GGT1 IL2 IL4
Entrez ID		3565	963
HPRD ID		00989	01054
Ensembl ID		ENSG00000113520	ENSG00000143119
Uniprot IDs		D4HNR6 P05112 Q5FC01	B4DQB5 P19397
PDB IDs		1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macrophage Activation Interleukin-4-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Macrophage Activation Response To Cytokine Signal Transduction Signaling Cell Communication Cellular Response To Organic Substance Cellular Response To Interleukin-4 Response To Interleukin-4 Cellular Response To Stimulus Inflammatory Response Cytokine-mediated Signaling Pathway Response To Organic Substance Immune Response Regulation Of Immune System Process Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Lung Goblet Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Interleukin-7-mediated Signaling Pathway Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Immune Response Response To Stimulus Cell Activation Negative Regulation Of T-helper 1 Cell Differentiation Mast Cell Differentiation Negative Regulation Of NAD(P)H Oxidase Activity Natural Killer Cell Chemotaxis B Cell Chemotaxis Neutrophil Extravasation Interleukin-2-mediated Signaling Pathway Mast Cell Chemotaxis Positive Regulation Of Protein Secretion Respiratory Burst Involved In Defense Response Positive Regulation Of Cell Differentiation Regulation Of Immune Response Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Immune System Process Immune System Process Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Chemokine Secretion Regulation Of T-helper 1 Cell Differentiation T Cell Chemotaxis Negative Regulation Of T-helper Cell Differentiation	Cell Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Lymphocyte Activation Lymphocyte Activation Regulation Of Isotype Switching To IgG Isotypes Cell Adhesion Regulation Of Cell Activation Leukocyte Activation Regulation Of T Cell Differentiation Regulation Of Immune System Process Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Differentiation Regulation Of Lymphocyte Differentiation Regulation Of Cell Adhesion Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Isotype Switching Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Isotype Switching Positive Regulation Of Immune System Process Regulation Of Inflammatory Response Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Activated T Cell Proliferation Positive Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Proliferation T Cell Selection Leukocyte Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Interferon-gamma Production Positive Regulation Of Cell Adhesion Regulation Of B Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Natural Killer Cell Activation
Tagcloud ?		abolished aerosols airway allergic antibodies asthma bal bronchoalveolar challenge challenged completely differentially directed eosinophil eosinophilia eosinophils gamma hyperresponsiveness ifn il5 infiltration lavage methacholine ovalbumin phenomena repeatedly sensitized subsequently tnf	bioinformatics coeruleus ctss cx3cr1 degs downloaded encyclopedia enriched excision genomes glycan gse34516 hub idiopathic igsf6 ipd kyoto laptm5 mismatch mortem omnibus ontology paired ppi ptprc slc5a7 spliceosome splicing transesterification
Tagcloud (Difference) ?		abolished aerosols airway allergic antibodies asthma bal bronchoalveolar challenge challenged completely differentially directed eosinophil eosinophilia eosinophils gamma hyperresponsiveness ifn il5 infiltration lavage methacholine ovalbumin phenomena repeatedly sensitized subsequently tnf	bioinformatics coeruleus ctss cx3cr1 degs downloaded encyclopedia enriched excision genomes glycan gse34516 hub idiopathic igsf6 ipd kyoto laptm5 mismatch mortem omnibus ontology paired ppi ptprc slc5a7 spliceosome splicing transesterification
Tagcloud (Intersection) ?