KLK3 and PZP

Number of citations of the paper that reports this interaction (PMID 1702714)
47

Data Source:
HPRD (in vitro)

		KLK3	PZP
Gene Name		kallikrein-related peptidase 3	pregnancy-zone protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Extracellular Vesicular Exosome	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis Negative Regulation Of Angiogenesis Cellular Protein Metabolic Process	Female Pregnancy Negative Regulation Of Endopeptidase Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		PCA3 expression level ( 23555189) Prostate cancer ( 18264097) Prostate-specific antigen levels ( 21160077 23269536)	Non-alcoholic fatty liver disease histology (AST) ( 20708005) Obesity-related traits ( 23251661)
Protein-Protein Interactions		14 interactors: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI	6 interactors: CPB2 KLK3 MMP2 MMP9 TGFB1 TGFB2
Entrez ID		354	5858
HPRD ID		01461	07178
Ensembl ID		ENSG00000142515	ENSG00000126838
Uniprot IDs		P07288 Q546G3
PDB IDs		1PFA 2PSA 2ZCH 2ZCK 2ZCL 3QUM
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Platelet Activation Blood Coagulation Hemostasis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Exocytosis Response To Wounding Acute-phase Response Negative Regulation Of Catalytic Activity Reproductive Process Regulation Of Cellular Protein Metabolic Process Secretion By Cell Regulation Of Protein Metabolic Process Acute Inflammatory Response Regulation Of Catalytic Activity Extracellular Matrix Disassembly Secretion Cell Activation Negative Regulation Of Cellular Metabolic Process Tissue Homeostasis Multicellular Organismal Homeostasis Female Pregnancy Response To Methanol Nipple Sheath Formation Mammary Gland Bud Elongation Vesicle-mediated Transport Endoderm Development Extracellular Matrix Organization Extracellular Structure Organization Maintenance Of Mitochondrion Location Erythropoietin-mediated Signaling Pathway Response To Triglyceride Negative Regulation Of Complement Activation, Lectin Pathway Response To Stress Inflammatory Response Response To Platinum Ion Mononuclear Cell Migration Hemolysis By Symbiont Of Host Erythrocytes	Extracellular Matrix Organization Extracellular Structure Organization Face Morphogenesis Regulation Of Extracellular Matrix Organization Head Morphogenesis Face Development Negative Regulation Of Macrophage Cytokine Production Body Morphogenesis Positive Regulation Of Epithelial Cell Migration Endoderm Development Extracellular Matrix Disassembly Blood Coagulation SMAD Protein Import Into Nucleus Hemostasis Negative Regulation Of Epithelial Cell Proliferation Pathway-restricted SMAD Protein Phosphorylation Regulation Of Fibrinolysis Regulation Of Epithelial Cell Migration Skeletal System Development Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell Morphogenesis Involved In Differentiation Female Pregnancy Fibrinolysis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Ossification Regulation Of Epithelial Cell Proliferation Endodermal Cell Differentiation Response To Hypoxia Positive Regulation Of Secretion Positive Regulation Of Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Salivary Gland Morphogenesis Positive Regulation Of Cell Motility Cell Morphogenesis Salivary Gland Development Positive Regulation Of Cellular Component Movement Response To Abiotic Stimulus Positive Regulation Of Locomotion Response To Progesterone Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Blood Coagulation Endoderm Formation SMAD Protein Signal Transduction Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition
Tagcloud ?		ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically	alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld ncan obtaining parvb patatin pnpla3 rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride
Tagcloud (Difference) ?		ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically	alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld ncan obtaining parvb patatin pnpla3 rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride
Tagcloud (Intersection) ?