IGFBP1 and MMP26

Number of citations of the paper that reports this interaction (PMID 12119297)
10

Data Source:
HPRD (in vivo, in vitro)

		IGFBP1	MMP26
Gene Name		insulin-like growth factor binding protein 1	matrix metallopeptidase 26
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Proteinaceous Extracellular Matrix
	Molecular Function	Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Growth Endoplasmic Reticulum Unfolded Protein Response Tissue Regeneration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process	Proteolysis Collagen Catabolic Process
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640)
Protein-Protein Interactions		4 interactors: IGF1 IGF2 MMP26 TF	3 interactors: IGFBP1 MMP9 SERPINA1
Entrez ID		3484	56547
HPRD ID		00897	05683
Ensembl ID		ENSG00000146678	ENSG00000167346
Uniprot IDs		P08833	Q9NRE1
PDB IDs		1ZT3 1ZT5 2DSQ
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Exocrine Pancreas Development Positive Regulation Of Glycogen Biosynthetic Process Platelet Activation Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Exocytosis Positive Regulation Of Glucose Metabolic Process Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Metabolic Process Positive Regulation Of Mitotic Nuclear Division Blood Coagulation Hemostasis Exocrine System Development Secretion By Cell Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Body Fluid Levels Positive Regulation Of Protein Kinase B Signaling Wound Healing Positive Regulation Of T Cell Proliferation Secretion Cell Activation Pancreas Development Response To Wounding Regulation Of Glucose Metabolic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Division Regulation Of T Cell Proliferation Digestive System Development Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Prostate Gland Stromal Morphogenesis Glycolate Metabolic Process Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Cycle Process Striated Muscle Cell Differentiation Negative Regulation Of Oocyte Development Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Division Positive Regulation Of Glycogen (starch) Synthase Activity Ossification Positive Regulation Of Cell Cycle	Response To Methanol Response To Triglyceride Response To Chromate Positive Regulation Of Receptor Binding Positive Regulation Of Keratinocyte Migration Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cation Channel Activity Macrophage Differentiation Response To Wounding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Lead Ion Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Endodermal Cell Differentiation Acute-phase Response Negative Regulation Of Transporter Activity Negative Regulation Of Ion Transmembrane Transport Tissue Regeneration Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Negative Regulation Of Transmembrane Transport Endoderm Formation
Tagcloud ?		blots compartments dependence detectable disturbances dot fresh granulosa igfs incubation lh messenger northern otherwise ovarian ovaries ovary pco polycystic ribonucleic stroma stromal theca thecal trophic weakly
Tagcloud (Difference) ?		blots compartments dependence detectable disturbances dot fresh granulosa igfs incubation lh messenger northern otherwise ovarian ovaries ovary pco polycystic ribonucleic stroma stromal theca thecal trophic weakly
Tagcloud (Intersection) ?