ICAM3 and EZR

Number of citations of the paper that reports this interaction (PMID 9705328)
60

Data Source:
BioGRID (pull down, affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		ICAM3	EZR
Gene Name		intercellular adhesion molecule 3	ezrin
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome	Ruffle Uropod Extracellular Space Nucleolus Cytosol Actin Filament Plasma Membrane Microvillus Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium T-tubule Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Ciliary Basal Body Cell Body Microspike Membrane Raft Apical Part Of Cell Cell Tip Extracellular Vesicular Exosome Cell Periphery Astrocyte Projection Schwann Cell Microvillus
	Molecular Function	Receptor Binding Integrin Binding Protein Binding	Protein Binding Protein Domain Specific Binding Poly(A) RNA Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Cell Adhesion Single Organismal Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response	Cytoskeletal Anchoring At Plasma Membrane Leukocyte Cell-cell Adhesion Axon Guidance Regulation Of Cell Shape Positive Regulation Of Gene Expression Membrane To Membrane Docking Microvillus Assembly Receptor Internalization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Actin Filament Bundle Assembly Establishment Of Endothelial Barrier
Pathways		Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Axon guidance L1CAM interactions Netrin-1 signaling Recycling pathway of L1
Drugs
Diseases
GWAS		Crohn's disease ( 21102463)
Protein-Protein Interactions		10 interactors: APP CD209 CLEC4M EZR ITGAD ITGAL ITGB2 MSN PRKCQ ZBTB16	49 interactors: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CFTR CLIC5 CTNNB1 DLG1 EGFR FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MPP3 MSN NF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 S100P SCYL3 SDC2 SELL SELP SLC9A3R1 SLC9A3R2 SPN TBC1D10A TMEM8B TSC1 VCAM1 WFDC1 WWOX
Entrez ID		3385	7430
HPRD ID		00889	00475
Ensembl ID		ENSG00000076662	ENSG00000092820
Uniprot IDs		P32942	P15311
PDB IDs		1T0P	1NI2
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Single Organismal Cell-cell Adhesion Cell Adhesion Immune System Process Activated T Cell Proliferation Immune Response Peptide Antigen Transport Membrane To Membrane Docking T Cell Proliferation Virion Attachment To Host Cell Locomotion Cell Activation Regulation Of T Cell Activation Regulation Of Immune System Process Defense Response Adhesion Of Symbiont To Host Innate Immune Response Movement Of Cell Or Subcellular Component Cellular Localization Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Lymphocyte Proliferation Extracellular Structure Organization Mononuclear Cell Proliferation Integrin-mediated Signaling Pathway Regulation Of Lymphocyte Activation Leukocyte Proliferation Cell Recognition Blood Coagulation Hemostasis Regulation Of T Cell Proliferation Regulation Of Cell Activation Heterotypic Cell-cell Adhesion Modulation By Virus Of Host Morphology Or Physiology Viral Genome Replication Intracellular Transport Of Virus Establishment Of Endothelial Barrier Regulation Of Body Fluid Levels Chemotaxis Positive Regulation Of T Cell Activation Wound Healing Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Leukocyte Migration Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Endocytosis Positive Regulation Of Cell-cell Adhesion Response To Wounding Endothelial Cell Development T Cell Aggregation	Cell Adhesion Single Organismal Cell-cell Adhesion Movement Of Cell Or Subcellular Component Locomotion Cell Migration Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Organic Substance Leukocyte Migration Regulation Of Signaling Leukocyte Cell-cell Adhesion Organ Development Membrane To Membrane Docking Positive Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Cell Differentiation Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Phosphorylation Cell Activation Apoptotic Process Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Immune Response System Development Response To Growth Factor Cell Death Anatomical Structure Development Death Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Multicellular Organismal Development Blood Coagulation Developmental Process Hemostasis Defense Response Response To Radiation Positive Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Stimulus Cell Development Regulation Of Body Fluid Levels
Tagcloud ?		br ccl20 ccl3 ccl4 csf2 csf3 cxcl1 cxcl12 discordances extremities figf grew igfbp1 iib il1alpha il1beta il6 il8 lymphatic matrigel mmp1 mmp13 mmp9 mts6 plaur plgf tnfrsf18 vegfa vegfc	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?		br ccl20 ccl3 ccl4 csf2 csf3 cxcl1 cxcl12 discordances extremities figf grew igfbp1 iib il1alpha il1beta il6 il8 lymphatic matrigel mmp1 mmp13 mmp9 mts6 plaur plgf tnfrsf18 vegfa vegfc	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?