XIAP and UBE2D3

Number of citations of the paper that reports this interaction (PMID 21113135)
52

Data Source:
BioGRID (pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down)

		XIAP	UBE2D3
Gene Name		X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase	ubiquitin-conjugating enzyme E2D 3
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule	Nucleoplasm Cytosol Plasma Membrane Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Apoptotic Process Cellular Response To DNA Damage Stimulus Wnt Signaling Pathway Protein Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Regulation Of Inflammatory Response Copper Ion Homeostasis Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Mitotic Spindle Assembly Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Polyubiquitination Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway DNA Repair Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Protein Ubiquitination BMP Signaling Pathway Negative Regulation Of Type I Interferon Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Hypoxia
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling SMAC binds to IAPs SMAC-mediated dissociation of IAP:caspase complexes SMAC-mediated apoptotic response Signaling by Wnt deactivation of the beta-catenin transactivating complex Apoptotic factor-mediated response TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Intrinsic Pathway for Apoptosis	Loss of Function of TGFBR2 in Cancer Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Negative regulators of RIG-I/MDA5 signaling Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Activated TLR4 signalling Generic Transcription Pathway Class I MHC mediated antigen processing & presentation Innate Immune System TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer MyD88-independent cascade Loss of Function of TGFBR1 in Cancer RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs		1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
Diseases
GWAS
Protein-Protein Interactions		67 interactors: ACVRL1 AFP AIFM1 AKT1 AKT2 BIRC5 BRCA1 CASP10 CASP3 CASP7 CASP9 CHEK1 CKS1B COMMD1 DIABLO DTX3 DYNLL2 ELAVL1 ERCC3 GSPT1 HTRA1 HTRA2 IKBKE INPP5D LONRF1 MAGED1 MAP3K2 MAP3K3 MAP3K7 NEK6 NOD1 NOD2 NOTCH1 RAF1 RFC5 RIPK1 RIPK2 RIPK3 RIPK4 SEPT4 SSX2IP STRADB STUB1 TAB1 TAB2 TBK1 TGFBR1 TRAF6 TRIM32 TRIM8 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2I UBE2J2 UBE2N UBE2V1 UBE2V2 UBE2W VPS37C WDYHV1 XAF1	180 interactors: AMBRA1 AMFR ARIH1 ARIH2 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRCA1 BTRC CADPS2 CBL CBLC CHFR CNOT4 CREB3L1 CREB3L2 CUL3 DBN1 DDX58 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL2 FBXO2 FBXO25 FBXO32 FBXW11 FBXW8 FOCAD FZR1 HDAC6 HERC1 HERC2 HUWE1 IKBKG ITCH KAT2B KIAA1107 LRSAM1 MAP3K1 MARCH3 MARCH5 MARCH7 MARCH8 MDM2 MDM4 MEX3B MGRN1 MIB1 MID1 MKRN1 MKRN3 MSL1 MSL2 MUL1 MYLIP NEDD4 NEDD4L NFKB1 NFKBIA NHLRC1 OTUB1 PARK2 PCNA PDCD5 PJA1 PJA2 POLL POLM PRPF19 RABGEF1 RBCK1 RBX1 RELA RFFL RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF168 RNF181 RNF185 RNF2 RNF220 RNF25 RNF26 RNF31 RNF38 RNF4 RNF41 RNF43 RNF5 RNF8 RPLP1 RSPRY1 SAT1 SH3RF1 SHARPIN SIAH1 SIAH2 SKP1 SMURF1 SMURF2 STAM2 STAU1 STK25 STUB1 SYVN1 TOPORS TRAF6 TRAIP TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM31 TRIM32 TRIM33 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM58 TRIM63 TRIM68 TRIM7 TRIM8 TUBA1A UBA1 UBA6 UBASH3B UBC UBE3A UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF2 WSB1 WWP2 XIAP XPNPEP1 ZNRF1 ZNRF2 ZNRF4
Entrez ID		331	7323
HPRD ID		02094	04269
Ensembl ID		ENSG00000101966	ENSG00000109332
Uniprot IDs		B2R9R2 P98170	D6RAH7 P61077
PDB IDs		1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48	1X23 2FUH 3L1Z 3RPG 3UGB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Apoptotic Process Activation Of Innate Immune Response Programmed Cell Death Cell Death Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Stress Positive Regulation Of Protein Modification Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Protein Metabolic Process Protein Polyubiquitination Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction By Phosphorylation Innate Immune Response Regulation Of Signal Transduction Cellular Protein Modification Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Metabolic Process Protein Ubiquitination Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Catalytic Activity Regulation Of Cell Death Apoptotic Signaling Pathway Regulation Of Signaling Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Apoptotic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Autoubiquitination Cellular Metabolic Process Proteolysis Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Protein Monoubiquitination Metabolic Process Protein K48-linked Ubiquitination Regulation Of Signal Transduction Regulation Of Protein Ubiquitination Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stress Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Metabolic Process Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Positive Regulation Of Protein Ubiquitination Response To Stress Negative Regulation Of Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Negative Regulation Of Signaling Response To Stimulus Histone Ubiquitination Regulation Of Cellular Protein Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Intracellular Signal Transduction
Tagcloud ?		anthracyclines antiapoptotic apaf bcp carbinol childhood coadministration cruciferous cure doxorubicin dramatic evidenced i3c iap1 indole innovative lymphoblastic modality nalm nontoxic noxa opportunities parp phytochemical potentiates puma topoisomerase vegetables xl	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube3a ubea5 ubiquinase
Tagcloud (Difference) ?		anthracyclines antiapoptotic apaf bcp carbinol childhood coadministration cruciferous cure doxorubicin dramatic evidenced i3c iap1 indole innovative lymphoblastic modality nalm nontoxic noxa opportunities parp phytochemical potentiates puma topoisomerase vegetables xl	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube3a ubea5 ubiquinase
Tagcloud (Intersection) ?