HSPA2 and MAP3K3

Number of citations of the paper that reports this interaction (PMID 1474216)
0

Data Source:
HPRD (in vivo)

		HSPA2	MAP3K3
Gene Name		heat shock 70kDa protein 2	mitogen-activated protein kinase kinase kinase 3
Image
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Mitochondrion Cytosol Cell Surface Membrane CatSper Complex Extracellular Vesicular Exosome Blood Microparticle	Intracellular Cytosol
	Molecular Function	Protein Binding ATP Binding Enzyme Binding Unfolded Protein Binding Glycolipid Binding	Protein Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Response To Unfolded Protein Male Meiosis Male Meiosis I Spermatid Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Positive Regulation Of P38MAPK Cascade
Pathways		HSF1-dependent transactivation Attenuation phase Meiotic synapsis Cellular response to heat stress Regulation of HSF1-mediated heat shock response	Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs
Diseases
GWAS			Height ( 21998595 22021425 18391951)
Protein-Protein Interactions		9 interactors: APP CDK1 EWSR1 HSPBP1 MAP3K3 MEOX2 PARP1 SAE1 TRIM38	44 interactors: BIRC2 BRCA1 CDC37 COPS5 GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K2 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 SQSTM1 TOM1L1 TRAF6 TRAF7 UBC VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16
Entrez ID		3306	4215
HPRD ID		07174	03965
Ensembl ID		ENSG00000126803	ENSG00000198909
Uniprot IDs		P54652	J3KRN4 J3QRB6 Q99759
PDB IDs		3I33 4FSV	2C60 2JRH 2O2V 2PPH
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Cellular Protein Metabolic Process Activation Of MAPKK Activity Neuron Death Cellular Protein Modification Process Pronuclear Fusion Regulation Of Mitotic Cell Cycle Response To Oxidative Stress Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Import Into Nucleus Cellular Response To Reactive Oxygen Species Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Modification-dependent Protein Catabolic Process SMT3-dependent Protein Catabolic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of Signal Transduction Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Catalytic Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Poly-ADP-ribosylation Collateral Sprouting In Absence Of Injury Regulation Of Growth Rate Positive Regulation Of Protein Ubiquitination Activation Of MAPK Activity Regulation Of Growth Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Protein Import Into Nucleus Regulation Of Signal Transduction Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process	Positive Regulation Of Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Programmed Cell Death Cell Death Positive Regulation Of Protein Serine/threonine Kinase Activity Death Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Cell Death Activation Of MAPK Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response JNK Cascade Signaling Response To Stress Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Cell Communication Signal Transduction By Phosphorylation Positive Regulation Of MAP Kinase Activity Regulation Of MAP Kinase Activity
Tagcloud ?		1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tac1 tmod1 xecd	11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a
Tagcloud (Difference) ?		1st barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tac1 tmod1 xecd	11ra cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a
Tagcloud (Intersection) ?		affymetrix