HSPA1A and NQO1

Number of citations of the paper that reports this interaction (PMID 11821413)
9

Data Source:
HPRD (in vitro)

		HSPA1A	NQO1
Gene Name		heat shock 70kDa protein 1A	NAD(P)H dehydrogenase, quinone 1
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centriole Cytosol Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Ribonucleoprotein Complex Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Cytoplasm Cytosol Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	Virus Receptor Activity G-protein Coupled Receptor Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Poly(A) RNA Binding Protein N-terminus Binding Unfolded Protein Binding	NAD(P)H Dehydrogenase (quinone) Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Superoxide Dismutase Activity Protein Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	MRNA Catabolic Process Response To Unfolded Protein Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Regulation Of Cell Death Negative Regulation Of Cell Growth Negative Regulation Of Protein Ubiquitination Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Protein Stabilization Negative Regulation Of Cell Death Cellular Heat Acclimation Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Regulation Of Cellular Amino Acid Metabolic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Synaptic Transmission, Cholinergic Aging Response To Nutrient Response To Toxic Substance Removal Of Superoxide Radicals Response To Estradiol Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Response To Ethanol Oxidation-reduction Process
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Viral RNP Complexes in the Host Cell Nucleus Attenuation phase Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA Influenza Infection Influenza Life Cycle HSF1-dependent transactivation Export of Viral Ribonucleoproteins from Nucleus	Regulation of ornithine decarboxylase (ODC) Metabolism of amino acids and derivatives
Drugs			Menadione Dicumarol Duroquinone 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol 5-Methoxy-1,2-Dimethyl-3-(4-Nitrophenoxymethyl)Indole-4,7-Dione Cibacron Blue Flavin-Adenine Dinucleotide 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione 2,5-Diaziridin-1-Yl-3-(Hydroxymethyl)-6-Methylcyclohexa-2,5-Diene-1,4-Dione Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE
Diseases
GWAS
Protein-Protein Interactions		79 interactors: AIFM1 APAF1 APEX1 APOB ATXN1 BAG1 BAG2 BAG3 BAG4 BCL2 BRSK1 CACNA1E CDK9 CFAP52 DAPP1 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJC3 DNAJC7 DYX1C1 EGFR EIF2AK2 FANCC FOS GPR37 GRIN1 GRIN2D HCFC1 HIVEP1 HMGA1 HSBP1 HSF1 HSP90AA1 HSPA8 HSPBP1 IKBKG KRT18 KRT7 MAP3K5 MAPRE1 METTL21A MOS MSR1 NQO1 NR3C1 PEX5 PLG POT1 PPP1R15A PRKCA PTGES3 PTMA RAP1A RAPGEF2 RHOA SAE1 SLC5A1 SNCA SNCB SNRK SOX9 ST13 STIP1 STUB1 TCERG1 TGM2 TOMM70A TP53 TRIAP1 TRIM24 TRIM38 TSSK6 TTC1 YWHAB YWHAG YWHAQ YWHAZ	5 interactors: DNAJB1 HSPA1A ING1 STUB1 TP53
Entrez ID		3303	1728
HPRD ID		00774	00518
Ensembl ID		ENSG00000204389	ENSG00000181019
Uniprot IDs		A8K5I0 B3KTT5 P08107	B4DLR8 P15559
PDB IDs		1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 4J8F	1D4A 1DXO 1GG5 1H66 1H69 1KBO 1KBQ 1QBG 2F1O 3JSX
Enriched GO Terms of Interacting Partners?		Protein Refolding Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Protein Folding Chaperone Cofactor-dependent Protein Refolding Response To Organic Substance Cellular Response To Stimulus Response To Stress Signaling Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Cell Communication Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Regulation Of Cellular Process Regulation Of Signal Transduction Regulation Of Cellular Component Organization Response To Abiotic Stimulus Positive Regulation Of Phosphorylation Negative Regulation Of Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Negative Regulation Of Biosynthetic Process Apoptotic Signaling Pathway Apoptotic Process	Negative Regulation Of Inclusion Body Assembly Response To Unfolded Protein Negative Regulation Of Cell Growth Regulation Of Cellular Component Organization Regulation Of Inclusion Body Assembly Protein Refolding Negative Regulation Of Growth Regulation Of Cellular Response To Heat Regulation Of Cell Growth Cellular Response To Heat Cellular Response To Stress Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Growth Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus ER-nucleus Signaling Pathway Negative Regulation Of Cell Proliferation Response To Heat Protein Import Into Nucleus Nuclear Import Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Macromitophagy Positive Regulation Of Chaperone-mediated Protein Complex Assembly Cellular Heat Acclimation Oligodendrocyte Apoptotic Process Protein Import Response To Endoplasmic Reticulum Stress Protein Localization To Nucleus Positive Regulation Of Protein Complex Assembly Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Organic Substance Negative Regulation Of Helicase Activity Response To Transforming Growth Factor Beta Response To Temperature Stimulus Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Chaperone Cofactor-dependent Protein Refolding Nucleocytoplasmic Transport Nuclear Transport Ubiquitin-dependent SMAD Protein Catabolic Process Mitochondrial DNA Repair Protein Folding
Tagcloud ?		chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	absorbance antioxidants assayed benzyl centrifugal edible fcpc fractionate hepa1c1c7 inducer isothiocyanate itc itcs leaves moringa nad nutritious oleifera orac oxidoreductase partition polyphenol polyphenols preparatory quinone rhamnosyloxy sf sulforaphane tropical
Tagcloud (Difference) ?		chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	absorbance antioxidants assayed benzyl centrifugal edible fcpc fractionate hepa1c1c7 inducer isothiocyanate itc itcs leaves moringa nad nutritious oleifera orac oxidoreductase partition polyphenol polyphenols preparatory quinone rhamnosyloxy sf sulforaphane tropical
Tagcloud (Intersection) ?