HRAS and PIK3CG

Number of citations of the paper that reports this interaction (PMID 11136978)
105

Data Source:
HPRD (in vitro)

		HRAS	PIK3CG
Gene Name		Harvey rat sarcoma viral oncogene homolog	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex, Class IB Membrane Mast Cell Granule
	Molecular Function	Protein Binding GTP Binding Protein C-terminus Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Ephrin Receptor Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Positive Regulation Of Protein Phosphorylation Endocytosis Chemotaxis Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Signal Transduction Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Negative Regulation Of Gene Expression Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac GTPase Activity Negative Regulation Of Rho GTPase Activity Positive Regulation Of Rac Protein Signal Transduction Social Behavior Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Epithelial Cell Proliferation Leukocyte Migration Striated Muscle Cell Differentiation Protein Heterooligomerization Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Wound Healing Cellular Senescence Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ruffle Assembly Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of MiRNA Metabolic Process	Angiogenesis Cytokine Production Adaptive Immune Response Dendritic Cell Chemotaxis Positive Regulation Of Acute Inflammatory Response Respiratory Burst Involved In Defense Response Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation T Cell Chemotaxis Negative Regulation Of Triglyceride Catabolic Process Phosphatidylinositol 3-kinase Signaling Platelet Activation Neutrophil Chemotaxis Secretory Granule Localization Regulation Of Cell Adhesion Mediated By Integrin Natural Killer Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process T Cell Proliferation T Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Small Molecule Metabolic Process Innate Immune Response Phosphatidylinositol Phosphorylation Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Cardiac Muscle Contraction Platelet Aggregation Neutrophil Extravasation Hepatocyte Apoptotic Process Negative Regulation Of Fibroblast Apoptotic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation CREB phosphorylation through the activation of Ras Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events EPH-Ephrin signaling SOS-mediated signalling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Signalling to RAS Downstream signal transduction Signaling by FGFR mutants Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-2 signaling Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation Transmission across Chemical Synapses Ras activation uopn Ca2+ infux through NMDA receptor Adaptive Immune System Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling Activation of NMDA receptor upon glutamate binding and postsynaptic events RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Post NMDA receptor activation events Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation SHC1 events in EGFR signaling RAF activation IRS-mediated signalling FRS2-mediated cascade Activation of RAS in B cells Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling Constitutive Signaling by EGFRvIII	Synthesis of PIPs at the plasma membrane Signaling by GPCR GPCR downstream signaling Metabolism of lipids and lipoproteins G-protein beta:gamma signalling G beta:gamma signalling through PI3Kgamma GPVI-mediated activation cascade Phospholipid metabolism Platelet activation, signaling and aggregation PI Metabolism
Drugs		Hexane-1,6-Diol Trifluoroethanol Guanosine-5\'-Triphosphate Guanosine-5\'-Diphosphate N,N\'-DIMETHYL-N-(ACETYL)-N\'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE	Staurosporine Myricetin 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One Quercetin 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE 5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Diseases
GWAS			Blood pressure ( 21909110) Carotid intima media thickness ( 21909108) Mean platelet volume ( 22139419 19820697 22423221) Platelet counts ( 22139419)
Protein-Protein Interactions		78 interactors: AGTR1 ARAF ARHGEF1 BCL2 BRAF BRAP CAV1 CDC25A CDC25C DEAF1 DGKZ FNTA FNTB FYN GPSM2 GRB2 GRIN1 GRIN2D ICMT IKZF3 IL3 INSR IRAK1 IRAK2 ITSN1 KRT18 LGALS1 MAP2K1 MAPK8 MLLT4 NF1 PDE6D PDGFB PIK3CA PIK3CD PIK3CG PIK3R1 PLCE1 PRKCI PRKCZ RABAC1 RABGEF1 RAF1 RALA RALGDS RAP1B RAP1GDS1 RAPGEF1 RARRES3 RASA1 RASGRF1 RASGRP1 RASGRP4 RASIP1 RASSF1 RASSF2 RASSF5 RGL1 RGL2 RGL4 RGS12 RHOD RIN1 RIT2 RNF115 SHOC2 SNRPE SNX17 SOS1 SOS2 SRC TIAM1 TLR2 TLR9 TP73 TTC1 VAV1 ZBTB12	22 interactors: ADRBK1 BCR CD28 EPHA8 GAB1 GRB2 GSN HRAS IL6ST KIT KRAS LYN NOTCH1 NRAS PIK3CD PIK3R5 PTPN11 SEC14L2 SET SMPD2 TPM2 ZNF282
Entrez ID		3265	5294
HPRD ID		01813	03135
Ensembl ID		ENSG00000174775	ENSG00000105851
Uniprot IDs		P01112	A8K9G9 P48736
PDB IDs		121P 1AA9 1AGP 1BKD 1CLU 1CRP 1CRQ 1CRR 1CTQ 1GNP 1GNQ 1GNR 1HE8 1IAQ 1IOZ 1JAH 1JAI 1K8R 1LF0 1LF5 1LFD 1NVU 1NVV 1NVW 1NVX 1P2S 1P2T 1P2U 1P2V 1PLJ 1PLK 1PLL 1Q21 1QRA 1RVD 1WQ1 1XCM 1XD2 1XJ0 1ZVQ 1ZW6 221P 2C5L 2CE2 2CL0 2CL6 2CL7 2CLC 2CLD 2EVW 2GDP 2LCF 2LWI 2Q21 2QUZ 2RGA 2RGB 2RGC 2RGD 2RGE 2RGG 2UZI 2VH5 2X1V 3DDC 3I3S 3K8Y 3K9L 3K9N 3KKM 3KKN 3KUD 3L8Y 3L8Z 3LBH 3LBI 3LBN 3LO5 3OIU 3OIV 3OIW 3RRY 3RRZ 3RS0 3RS2 3RS3 3RS4 3RS5 3RS7 3RSL 3RSO 3TGP 421P 4DLR 4DLS 4DLT 4DLU 4DLV 4DLW 4DLX 4DLY 4DLZ 4DST 4DSU 4EFL 4EFM 4EFN 4G0N 4G3X 4K81 4Q21 521P 5P21 621P 6Q21 721P 821P	1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3APC 3APD 3APF 3CSF 3CST 3DBS 3DPD 3ENE 3IBE 3L08 3L13 3L16 3L17 3L54 3LJ3 3MJW 3ML8 3ML9 3NZS 3NZU 3OAW 3P2B 3PRE 3PRZ 3PS6 3QAQ 3QAR 3QJZ 3QK0 3R7Q 3R7R 3S2A 3SD5 3T8M 3TJP 3TL5 3ZVV 3ZW3 4ANU 4ANV 4ANW 4ANX 4AOF 4DK5 4EZJ 4EZK 4EZL 4F1S 4FA6 4FAD 4FHJ 4FHK 4FJY 4FJZ 4FLH 4FUL 4G11 4GB9 4HLE 4KZ0 4KZC
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Signal Transduction Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signaling Cell Communication Small GTPase Mediated Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Cellular Response To Stimulus Ras Protein Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Regulation Of Ras Protein Signal Transduction Positive Regulation Of Hydrolase Activity Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Cellular Response To Organic Substance Regulation Of GTPase Activity Regulation Of Cellular Process Positive Regulation Of GTPase Activity Response To Organic Substance Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Regulation Of Phosphorylation Platelet Activation Response To Wounding Positive Regulation Of Protein Modification Process Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Immune System Process Cell Activation Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Phosphatidylinositol-mediated Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Response To Organic Substance Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Leukocyte Migration Regulation Of Intracellular Signal Transduction Innate Immune Response Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Immune Response Defense Response Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Response To External Stimulus Positive Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Cell Migration Wound Healing Regulation Of Catalytic Activity Chemotaxis Positive Regulation Of Phosphorylation Cell Motility Regulation Of Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Insulin Receptor Signaling Pathway Signal Transduction Regulation Of Phosphorylation Response To Wounding Regulation Of MAP Kinase Activity
Tagcloud ?		12th arising arose carcinogenic carrying clustered codon contain detectable epithelium find fraction gaa gga gland indirectly mammary measure methylurea mutants nitroso nmu organ origin preexisting sectors transition untreated	422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk2 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides prostate proteases pseudogene repeats share silico talk
Tagcloud (Difference) ?		12th arising arose carcinogenic carrying clustered codon contain detectable epithelium find fraction gaa gga gland indirectly mammary measure methylurea mutants nitroso nmu organ origin preexisting sectors transition untreated	422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk2 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides prostate proteases pseudogene repeats share silico talk
Tagcloud (Intersection) ?