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HPS1 and HPS4
Number of citations of the paper that reports this interaction (PMID
12756248
)
26
Data Source:
HPRD
(in vivo)
HPS1
HPS4
Gene Name
Hermansky-Pudlak syndrome 1
Hermansky-Pudlak syndrome 4
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Lysosome
Integral Component Of Plasma Membrane
Cytoplasmic Membrane-bounded Vesicle
BLOC-3 Complex
Cytoplasm
Lysosome
Membrane
BLOC-3 Complex
Melanosome
Platelet Dense Granule
Molecular Function
Protein Binding
Protein Dimerization Activity
Protein Binding
Protein Homodimerization Activity
Protein Dimerization Activity
Biological Process
Lysosome Organization
Blood Coagulation
Visual Perception
Melanocyte Differentiation
Positive Regulation Of Natural Killer Cell Activation
Secretion Of Lysosomal Enzymes
Eye Pigmentation
Retina Development In Camera-type Eye
Protein Targeting
Lysosome Organization
Blood Coagulation
Hemostasis
Melanocyte Differentiation
Positive Regulation Of Eye Pigmentation
Protein Stabilization
Pathways
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
2 interactors:
HPS4
PSEN2
2 interactors:
HPS1
RAC1
Entrez ID
3257
89781
HPRD ID
05403
05983
Ensembl ID
ENSG00000107521
ENSG00000100099
Uniprot IDs
Q658M9
Q92902
A8K2E6
Q6P1K3
Q9NQG7
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Eye Pigmentation
Regulation Of Eye Pigmentation
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Developmental Pigmentation
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Membrane Protein Ectodomain Proteolysis
Beta-amyloid Metabolic Process
Amyloid Precursor Protein Metabolic Process
Notch Receptor Processing
Regulation Of Developmental Pigmentation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Epithelium Development
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Endoplasmic Reticulum Calcium Ion Homeostasis
Dorsal/ventral Neural Tube Patterning
Membrane Protein Proteolysis
Positive Regulation Of Coagulation
Melanocyte Differentiation
Brain Morphogenesis
Protein Transport
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Establishment Of Protein Localization
Neuroepithelial Cell Differentiation
Cardiac Muscle Contraction
Lung Alveolus Development
Negative Regulation Of Protein Binding
Lysosome Organization
Thymus Development
Neural Tube Patterning
Regulation Of Protein Tyrosine Kinase Activity
Heart Contraction
Tissue Development
T Cell Activation Involved In Immune Response
Developmental Pigmentation
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Protein Localization
Somitogenesis
Striated Muscle Contraction
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Protein Stabilization
Hair Follicle Development
Hair Cycle Process
Cell Fate Specification
Somite Development
Negative Regulation Of Binding
Ephrin Receptor Signaling Pathway
Vacuole Organization
Hair Cycle
Embryonic Olfactory Bulb Interneuron Precursor Migration
Negative Regulation Of Interleukin-23 Production
Positive Regulation Of Cell Activation
Engulfment Of Apoptotic Cell
Regulation Of Lymphocyte Activation
Mast Cell Chemotaxis
Blood Coagulation
Hemostasis
Regulation Of Cell Activation
Eye Pigmentation
Epithelial Cell Differentiation
Secretion Of Lysosomal Enzymes
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Regulation Of Body Fluid Levels
Sensory Organ Development
Wound Healing
Olfactory Bulb Interneuron Development
Regulation Of Hydrogen Peroxide Metabolic Process
Response To Wounding
Regulation Of Respiratory Burst
Auditory Receptor Cell Morphogenesis
Phagocytosis, Engulfment
Olfactory Bulb Interneuron Differentiation
Positive Regulation Of Lamellipodium Assembly
Auditory Receptor Cell Development
Positive Regulation Of Immune System Process
Dopaminergic Neuron Differentiation
Membrane Invagination
Positive Regulation Of Lamellipodium Organization
Negative Regulation Of Receptor-mediated Endocytosis
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Anatomical Structure Arrangement
Ruffle Assembly
Hyperosmotic Response
Positive Regulation Of Neutrophil Chemotaxis
Regulation Of Lamellipodium Assembly
Positive Regulation Of Focal Adhesion Assembly
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Adherens Junction Organization
Cochlea Morphogenesis
Positive Regulation Of Natural Killer Cell Activation
Epithelium Development
Positive Regulation Of Granulocyte Chemotaxis
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Regulation Of Neutrophil Chemotaxis
Regulation Of Neutrophil Migration
Non-canonical Wnt Signaling Pathway
Apoptotic Cell Clearance
Auditory Receptor Cell Differentiation
Tagcloud
?
abnormal
ad
appear
appsw
brains
damaged
excessive
find
gtpases
happ
hippocampal
impair
mfn1
mfn2
mitochondria
mitochondrial
mitofusin
morphology
neurogenesis
obscure
pathogenesis
plaque
preventive
propose
prp
sh
swedish
sy5y
theanine
Tagcloud (Difference)
?
abnormal
ad
appear
appsw
brains
damaged
excessive
find
gtpases
happ
hippocampal
impair
mfn1
mfn2
mitochondria
mitochondrial
mitofusin
morphology
neurogenesis
obscure
pathogenesis
plaque
preventive
propose
prp
sh
swedish
sy5y
theanine
Tagcloud (Intersection)
?