HPR and IGHM

Number of citations of the paper that reports this interaction (PMID 10085035)
23

Data Source:
HPRD (in vitro)

		HPR	IGHM
Gene Name		haptoglobin-related protein	immunoglobulin heavy constant mu
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Spherical High-density Lipoprotein Particle Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle
	Molecular Function	Catalytic Activity Hemoglobin Binding	Single-stranded DNA Binding Antigen Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding
	Biological Process	Receptor-mediated Endocytosis Metabolic Process	Adaptive Immune Response Antibacterial Humoral Response Innate Immune Response Defense Response To Gram-negative Bacterium
Pathways		Scavenging of heme from plasma
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolite levels ( 22916037)
Protein-Protein Interactions		3 interactors: APOA1 IGHM VKORC1	19 interactors: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 IGJ MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1L VPREB1 VPREB3 ZAK
Entrez ID		3250	3507
HPRD ID		00773	00912
Ensembl ID		ENSG00000261701
Uniprot IDs		P00739
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Negative Regulation Of Interleukin-1 Secretion High-density Lipoprotein Particle Clearance Protein Oxidation Vitamin K Metabolic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Blood Coagulation Hemostasis Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Intestinal Cholesterol Absorption Phospholipid Homeostasis Peptidyl-methionine Modification Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Phospholipid Efflux Regulation Of Cytokine Secretion Involved In Immune Response Peptidyl-glutamic Acid Carboxylation Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Lipoprotein Lipase Activity Regulation Of Body Fluid Levels Negative Regulation Of Interleukin-1 Beta Production Wound Healing Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway High-density Lipoprotein Particle Remodeling Glucocorticoid Metabolic Process Protein-lipid Complex Assembly Endothelial Cell Proliferation Reverse Cholesterol Transport Negative Chemotaxis Response To Wounding Negative Regulation Of Lipase Activity Regulation Of Interleukin-1 Beta Secretion Phosphatidylcholine Biosynthetic Process Response To Stress Antibacterial Humoral Response Positive Regulation Of Lipid Catabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Steroid Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Antimicrobial Humoral Response Cholesterol Efflux Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Fatty Acid Metabolic Process	Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Response To External Stimulus Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation ER Overload Response Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Endocytosis Axon Guidance Innate Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Negative Regulation Of Neuron Differentiation Regulation Of Signal Transduction Vesicle-mediated Transport Platelet Activation Immune System Process Axonogenesis Central Nervous System Development Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Axon Development Regulation Of Signaling Cell Morphogenesis Involved In Neuron Differentiation Cellular Response To Growth Factor Stimulus Cell Death Death Chemotaxis Response To Growth Factor Regulation Of Catalytic Activity Regulation Of Protein Folding In Endoplasmic Reticulum Fetal Process Involved In Parturition Regulation Of MAPK Cascade Neuron Projection Morphogenesis System Development Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Neurogenesis
Tagcloud ?		47d anchorage chemoprevention efficient enables equally exerted feulgen heterodimers hi hs ineffective insensitive isotypes lgd macroscopic marginal mxt polymorphic progestagen relates retinoids ru rxr tamoxifen transglutaminase triggering ttnpb weak	aap aat affymetrix alopecia areata ccl5 cd27 cx3cl1 cxcl10 cxcr5 degs distinctly ereg etiopathogenesis favoring fgf18 fgf5 foxc2 hair hu95a icam2 icam3 ighg3 il7r lck lesional separating sfn v2
Tagcloud (Difference) ?		47d anchorage chemoprevention efficient enables equally exerted feulgen heterodimers hi hs ineffective insensitive isotypes lgd macroscopic marginal mxt polymorphic progestagen relates retinoids ru rxr tamoxifen transglutaminase triggering ttnpb weak	aap aat affymetrix alopecia areata ccl5 cd27 cx3cl1 cxcl10 cxcr5 degs distinctly ereg etiopathogenesis favoring fgf18 fgf5 foxc2 hair hu95a icam2 icam3 ighg3 il7r lck lesional separating sfn v2
Tagcloud (Intersection) ?