HPD and HIVEP1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HPD	HIVEP1
Gene Name		4-hydroxyphenylpyruvate dioxygenase	human immunodeficiency virus type I enhancer binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	4-hydroxyphenylpyruvate Dioxygenase Activity Metal Ion Binding	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	L-phenylalanine Catabolic Process Tyrosine Catabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated
Pathways		Phenylalanine and tyrosine catabolism Metabolism of amino acids and derivatives
Drugs		Nitisinone (1-Tert-Butyl-5-Hydroxy-1h-Pyrazol-4-Yl)-(6-Methanesulfonyl-4\'-Methoxy-2-Methyl-Biphenyl-3-Yl)-Methanone
Diseases
GWAS		Obesity-related traits ( 23251661) Urinary metabolites ( 21572414)	Alcohol and nictotine co-dependence ( 22488850)
Protein-Protein Interactions		4 interactors: CDKN1A HIVEP1 HRSP12 IKBKG	35 interactors: ALDOB APH1A APTX ASGR1 ATXN1 ATXN1L BHLHE40 BNIP3 BRCA1 CACNA1A DNAJA1 EMG1 GAA GSDMB HPD HRSP12 HSPA1A IMMT MAGED1 MAPK14 MAPK8 MTMR3 NHLH1 NINJ1 NUCB1 PRKAR1A RAB1A SDCBP SERTAD1 SMAD3 SNX4 SOCS3 SOX10 STAT3 TMEM176A
Entrez ID		3242	3096
HPRD ID		02041	01925
Ensembl ID		ENSG00000158104	ENSG00000095951
Uniprot IDs		P32754	P15822
PDB IDs		3ISQ	1BBO 3ZNF 4ZNF
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Intestinal Epithelial Cell Maturation Cellular Response To UV-B Immune Response-regulating Cell Surface Receptor Signaling Pathway Stress-induced Premature Senescence Regulation Of Gene Expression Regulation Of Translational Termination Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Kinase Activity Mitotic Cell Cycle Arrest Response To UV-B Intestinal Epithelial Cell Development Regulation Of Protein Metabolic Process Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Transferase Activity Intestinal Epithelial Cell Differentiation Epithelial Cell Maturation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Response To Arsenic-containing Substance Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Senescence Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of NIK/NF-kappaB Signaling Response To X-ray Positive Regulation Of Protein Phosphorylation Response To Hyperoxia Regulation Of Protein Kinase Activity Response To Corticosterone B Cell Homeostasis Regulation Of Kinase Activity NIK/NF-kappaB Signaling Response To Mineralocorticoid Regulation Of NIK/NF-kappaB Signaling Innate Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of B Cell Proliferation Cellular Response To DNA Damage Stimulus Positive Regulation Of Phosphorylation Regulation Of Immune Response Columnar/cuboidal Epithelial Cell Development Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA Biosynthetic Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process	Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Cell Death Regulation Of Cell Death Neurotrophin Signaling Pathway Regulation Of Signaling Regulation Of Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Stress Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Growth Regulation Of Phosphorylation Glucose Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Cell Death Death Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Cell Death Regulation Of Cellular Component Organization Negative Regulation Of Phosphorylation Hexose Metabolic Process Positive Regulation Of Organelle Organization
Tagcloud ?		agers agricultural compliance conduct conservation describes educational eighty farm feasible greatest hcp hearing hpds industrial intention junior loud multicomponent noise persuade school schools senior students surveys teen working yearly	16q22 aboriginal cholestasis cirh1a cirhin cirip cirrhosis collaboration evolves focuses helped hopital indian justine mapped naic nations northwestern nucleolus portal quebec r565w researchers splice ste tex292 twelve varices wd40
Tagcloud (Difference) ?		agers agricultural compliance conduct conservation describes educational eighty farm feasible greatest hcp hearing hpds industrial intention junior loud multicomponent noise persuade school schools senior students surveys teen working yearly	16q22 aboriginal cholestasis cirh1a cirhin cirip cirrhosis collaboration evolves focuses helped hopital indian justine mapped naic nations northwestern nucleolus portal quebec r565w researchers splice ste tex292 twelve varices wd40
Tagcloud (Intersection) ?