HNRNPL and HMG20B

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HNRNPL	HMG20B
Gene Name		heterogeneous nuclear ribonucleoprotein L	high mobility group 20B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Ribonucleoprotein Complex Extracellular Vesicular Exosome	Nucleoplasm Chromosome
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding	DNA Binding Chromatin Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing Gene Expression	Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Cycle Blood Coagulation Negative Regulation Of Protein Sumoylation Skeletal Muscle Cell Differentiation Positive Regulation Of Neuron Differentiation
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APEX1 CSE1L CSNK2A1 FGFR3 HIST3H3 HMG20B HMGA1 HNRNPA2B1 HNRNPK IL7R ITCH NEDD4 PCBP2 PJA1 PTBP1 SUMO4	15 interactors: APP BRCA2 CCDC102B CCDC136 CCDC85B HNRNPL KIF4A KRT15 KRT38 NKX3-1 PHF21A SYCE1 TACC2 TFIP11 VIM
Entrez ID		3191	10362
HPRD ID		04360	05703
Ensembl ID		ENSG00000104824	ENSG00000064961
Uniprot IDs		P14866 Q6NTA2	Q9P0W2
PDB IDs		3R27 3TO8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing Negative Regulation Of RNA Splicing Regulation Of RNA Metabolic Process Negative Regulation Of Defense Response To Virus MRNA Processing Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Cellular Metabolic Process MRNA Metabolic Process Positive Regulation Of Protein Catabolic Process Viral Process Negative Regulation Of Type I Interferon Production RNA Processing RNA Metabolic Process Negative Regulation Of Mitotic Nuclear Division Protein Modification By Small Protein Conjugation Protein Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Response To Virus Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Transmission Of Virus Development Involved In Symbiotic Interaction Catabolic Process Positive Regulation Of Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Gene Expression Base-excision Repair Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Immune Response Telomere Maintenance Negative Regulation Of Gene Expression Negative Regulation Of Cell Division Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Interleukin-7-mediated Signaling Pathway Oncogene-induced Cell Senescence Regulation Of Defense Response To Virus Negative Regulation Of Biosynthetic Process	Positive Regulation Of Mitotic Cell Cycle Suckling Behavior Cell Cycle Process Developmental Process Axon Cargo Transport Cell Cycle Positive Regulation Of Cell Cycle Microtubule-based Process Spliceosomal Complex Disassembly Anatomical Structure Development Regulation Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Positive Regulation Of Androgen Secretion Apoptotic Process Feeding Behavior Central Nervous System Development MRNA Processing Blood Coagulation Cell Division Hemostasis Programmed Cell Death Microtubule Cytoskeleton Organization Meiosis I Cytokinesis Cell Death Death Collateral Sprouting In Absence Of Injury Negative Regulation Of Estrogen Receptor Binding System Development Cytoskeleton Organization Organ Development Spindle Organization Negative Regulation Of Epithelial Cell Proliferation Microtubule-based Transport MRNA Metabolic Process Cytoskeleton-dependent Intracellular Transport Organelle Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Binding Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Peptidase Activity Cell Maturation RNA Processing RNA Metabolic Process Regulation Of Body Fluid Levels Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Wound Healing Nucleobase-containing Compound Metabolic Process
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