HMOX1 and TUT1

Number of citations of the paper that reports this interaction (PMID 21102410)
7

Data Source:
BioGRID (unspecified method)

		HMOX1	TUT1
Gene Name		heme oxygenase (decycling) 1	terminal uridylyl transferase 1, U6 snRNA-specific
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Caveola Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Nucleolus MRNA Cleavage And Polyadenylation Specificity Factor Complex Nuclear Speck Intercellular Bridge
	Molecular Function	Heme Oxygenase (decyclizing) Activity Phospholipase D Activity Signal Transducer Activity Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding	RNA Binding MRNA 3'-UTR Binding Polynucleotide Adenylyltransferase Activity Protein Binding ATP Binding Enzyme Binding Metal Ion Binding RNA Uridylyltransferase Activity
	Biological Process	Angiogenesis Endothelial Cell Proliferation Wound Healing Involved In Inflammatory Response Negative Regulation Of Leukocyte Migration Porphyrin-containing Compound Metabolic Process Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Small GTPase Mediated Signal Transduction Excretion Regulation Of Blood Pressure Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Muscle Cell Apoptotic Process Smooth Muscle Hyperplasia Cellular Response To Nutrient Negative Regulation Of Mast Cell Cytokine Production Erythrocyte Homeostasis Low-density Lipoprotein Particle Clearance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Response To Nicotine Intracellular Signal Transduction Heme Catabolic Process Response To Hydrogen Peroxide Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mast Cell Degranulation Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Response To Estrogen Small Molecule Metabolic Process Positive Regulation Of Chemokine Biosynthetic Process Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Vasodilation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Homooligomerization Iron Ion Homeostasis Transmembrane Transport Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Cellular Response To Hypoxia Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	MRNA Polyadenylation MRNA Cleavage SnRNA Processing Histone MRNA Catabolic Process
Pathways		Iron uptake and transport Metabolism of porphyrins Heme degradation
Drugs		NADH Formic Acid Biliverdine Ix Alpha 12-Phenylheme Heme 2-Phenylheme Verdoheme 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: AKT1 ASL BLVRB CCDC155 CPSF1 NOS1 POR POT1 TERF1 TUT1	3 interactors: HMOX1 IL32 PIN1
Entrez ID		3162	64852
HPRD ID		00782	15226
Ensembl ID		ENSG00000100292	ENSG00000149016
Uniprot IDs		P09601 Q6FH11	F5H0R1 Q9H6E5
PDB IDs		1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM	2E5G
Enriched GO Terms of Interacting Partners?		Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Arginine Catabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Negative Regulation Of Catalytic Activity Regulation Of Telomere Maintenance Via Telomerase Reactive Oxygen Species Metabolic Process Nitric Oxide Biosynthetic Process Positive Regulation Of Organelle Organization Regulation Of Telomerase Activity MRNA Cleavage Arginine Metabolic Process Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Monooxygenase Activity MRNA Polyadenylation Regulation Of Chromosome Organization Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Sodium Ion Transport RNA Polyadenylation Positive Regulation Of Oxidoreductase Activity Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Cellular Metabolic Process Negative Regulation Of Transferase Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Sodium Ion Transport Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Telomere Maintenance Regulation Of Organelle Organization Negative Regulation Of Protein Processing Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Nitrate Catabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Cellular Organofluorine Metabolic Process Positive Regulation Of DNA Strand Elongation Chromosome Localization To Nuclear Envelope Involved In Synapsis Nitric Oxide Catabolic Process Catabolic Process Regulation Of Oxidoreductase Activity MRNA 3'-end Processing Negative Regulation Of Hydrolase Activity	Defense Response Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Negative Regulation Of Locomotion Smooth Muscle Hyperplasia Negative Regulation Of Mast Cell Cytokine Production Smooth Muscle Adaptation Negative Regulation Of Mast Cell Degranulation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Immune System Process Negative Regulation Of Mast Cell Activation Involved In Immune Response Heme Catabolic Process Wound Healing Involved In Inflammatory Response Heme Oxidation Cellular Response To Arsenic-containing Substance Negative Regulation Of Mast Cell Activation Positive Regulation Of Chemokine Biosynthetic Process Regulation Of Cytokine Production Cellular Response To Iron Ion Regulation Of Cell Motility Cellular Response To Cadmium Ion Endothelial Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Regulation Of Locomotion Regulation Of Cellular Component Movement Negative Regulation Of Leukocyte Migration Low-density Lipoprotein Particle Clearance Response To Stress Regulation Of Mast Cell Degranulation Response To Arsenic-containing Substance Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Vasodilation Response To Iron Ion Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of Mast Cell Activation Plasma Lipoprotein Particle Clearance Negative Regulation Of Exocytosis Regulation Of Regulated Secretory Pathway Response To Nicotine Cellular Response To Nutrient Heme Metabolic Process Positive Regulation Of Chemokine Production Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Type I Interferon Production Negative Regulation Of DNA Binding Regulation Of Vasodilation Excretion Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Signal Transduction
Tagcloud ?		alters antioxidative bax cytotoxicity demonstrating ebp endonuclease endoplasmic expressions heme homologous immunoglobulin induces inositol messenger morphological nrf2 overproduction oxygenase reduces requiring simultaneously splicing stimulates tcp trichlorophenol triggered upregulates xbp1	1c 29a able adjacent cdna downregulated enforced inhibit interfering knockdown lipogenesis mg63 microarrays microrna nucleotidyl oligos osteosarcoma ppargamma prepared promoted regulators sirna srebp suppressor tissues transferase u2os upregulation way
Tagcloud (Difference) ?		alters antioxidative bax cytotoxicity demonstrating ebp endonuclease endoplasmic expressions heme homologous immunoglobulin induces inositol messenger morphological nrf2 overproduction oxygenase reduces requiring simultaneously splicing stimulates tcp trichlorophenol triggered upregulates xbp1	1c 29a able adjacent cdna downregulated enforced inhibit interfering knockdown lipogenesis mg63 microarrays microrna nucleotidyl oligos osteosarcoma ppargamma prepared promoted regulators sirna srebp suppressor tissues transferase u2os upregulation way
Tagcloud (Intersection) ?