HLA-A and PDIA3

Number of citations of the paper that reports this interaction (PMID 9545232)
23

Data Source:
HPRD (in vitro, in vivo)

		HLA-A	PDIA3
Gene Name		major histocompatibility complex, class I, A	protein disulfide isomerase family A, member 3
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Medial Cisterna Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Endoplasmic Reticulum Exit Site Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Cell Surface Melanosome Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding T Cell Receptor Binding Poly(A) RNA Binding TAP Binding	Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Viral Process Detection Of Bacterium Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Memory T Cell Activation	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Folding Proteolysis Protein Import Into Nucleus Protein Retention In ER Lumen Signal Transduction Protein N-linked Glycosylation Via Asparagine Response To Endoplasmic Reticulum Stress Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Post-translational Protein Modification Cellular Protein Metabolic Process Cell Redox Homeostasis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Antigen processing-Cross presentation ER-Phagosome pathway Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle
Drugs
Diseases
GWAS		Adverse response to carbamapezine ( 21149285) Beta-2 microglubulin plasma levels ( 23417110) Complement C3 and C4 levels ( 23028341) Crohn's disease ( 22412388) Drug-induced liver injury (amoxicillin-clavulanate) ( 21570397) HIV-1 control ( 20041166) IgA nephropathy ( 22197929) IgE levels ( 22075330) Nasopharyngeal carcinoma ( 19664746 20512145) Vitiligo ( 20410501)
Protein-Protein Interactions		25 interactors: APLP2 B2M BCAP31 CALR CANX CD8A DEK DERL1 ERBB2 KIR3DL2 LILRB1 LILRB2 MAGEA1 MAGEA4 MEOX2 PDIA3 PRKAR1A PRKCA SRC STAT3 TAPBP TRA TRB UBB ZDHHC17	15 interactors: APP BACE1 CALR CANX ERO1L ERP27 GYPC HLA-A IFNG MDM2 SLC12A3 SLC2A1 STAT3 SUMO4 TAP1
Entrez ID		3105	2923
HPRD ID		00826	03625
Ensembl ID		ENSG00000206503	ENSG00000167004
Uniprot IDs		B1PKY1 B2R7U3 P04439 P30443 Q5SUL5	G5EA52 P30101
PDB IDs		1W72 2XPG 3BO8 3RL1 3RL2	2ALB 2DMM 2H8L 3F8U
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Immune System Process Antigen Processing And Presentation Of Peptide Antigen Defense Response Neurotrophin TRK Receptor Signaling Pathway Signaling Neurotrophin Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cell Communication Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Immune Response Regulation Of Immune System Process Signal Transduction Homeostatic Process Cellular Response To Organic Substance Response To Stress Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Chemical Homeostasis Regulation Of Immune Response Regulation Of Signaling Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Response To Stimulus Regulation Of Protein Kinase Activity Fc Receptor Mediated Inhibitory Signaling Pathway Cellular Response To Stimulus Regulation Of Kinase Activity Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Viral Process Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Immune Response-inhibiting Signal Transduction Response To Growth Factor Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Dendritic Cell Differentiation Negative Regulation Of T Cell Proliferation Protein Transport	Antigen Processing And Presentation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Localization To Nucleus Chaperone-mediated Protein Folding Antigen Processing And Presentation Of Peptide Antigen Cellular Localization Response To Stress Protein Maturation By Protein Folding Endoplasmic Reticulum Unfolded Protein Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cellular Response To Unfolded Protein Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cytoplasmic Transport Negative Regulation Of Cell Development ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Antigen Processing And Presentation Of Endogenous Antigen Establishment Of Localization In Cell Defense Response Homeostatic Process Response To Unfolded Protein Immune System Process Chemical Homeostasis Establishment Of Protein Localization Intracellular Transport Response To Endoplasmic Reticulum Stress Response To Drug Protein Localization To Organelle Viral Process Intracellular Receptor Signaling Pathway Response To Estrogen Protein Maturation Transport Cellular Response To Organic Substance Protein Localization Nucleocytoplasmic Transport Nuclear Transport Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein Folding Regulation Of Neurogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Neurogenesis Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Negative Regulation Of Cell Differentiation Cellular Protein Localization Calcium Ion Homeostasis Peptide Antigen Assembly With MHC Class I Protein Complex
Tagcloud ?			calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia2 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization
Tagcloud (Difference) ?			calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia2 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization
Tagcloud (Intersection) ?