UBE2K and TRIM3

Number of citations of the paper that reports this interaction (PMID 11513855)
6

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		UBE2K	TRIM3
Gene Name		ubiquitin-conjugating enzyme E2K	tripartite motif containing 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Actin Cytoskeleton Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Cytoplasm Early Endosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination	Nervous System Development Protein Transport Protein Ubiquitination
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS
Protein-Protein Interactions		68 interactors: AMFR ANAPC11 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 FZR1 HTT ITCH ITSN1 LRSAM1 MARCH3 MARCH7 MDM2 MID1 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PIAS4 PRPF40A PRRG4 RBCK1 REL RING1 RNF111 RNF114 RNF125 RNF138 RNF144A RNF167 RNF2 RNF32 RNF4 RNF41 RNF5 SIAH1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 UBA1 UBC UBE2I UBOX5 UHRF2 WWP2 ZDHHC17	8 interactors: ACTN4 KIF21B MYO5A TNFAIP3 UBE2D4 UBE2G2 UBE2K UBE2U
Entrez ID		3093	10612
HPRD ID		04165	05690
Ensembl ID		ENSG00000078140	ENSG00000110171
Uniprot IDs		B4DIZ2 P61086	B7Z5Y8 O75382
PDB IDs		1YLA 2O25 3E46 3F92 3K9O 3K9P
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Proteolysis Proteasomal Protein Catabolic Process Apoptotic Process Programmed Cell Death Cell Death Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Metabolic Process Regulation Of Apoptotic Process Catabolic Process Protein Autoubiquitination Positive Regulation Of Signal Transduction Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of RNA Biosynthetic Process Viral Process Neuron Apoptotic Process Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Viral Release From Host Cell Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Neuron Death Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle	Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of CD40 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Osteoclast Proliferation Tolerance Induction To Lipopolysaccharide Cellular Protein Catabolic Process Cellular Protein Metabolic Process Protein Catabolic Process Proteolysis Protein Localization To Tight Junction Endoplasmic Reticulum Localization Regulation Of CD40 Signaling Pathway Vesicle Transport Along Actin Filament Positive Regulation Of Pinocytosis Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Vascular Wound Healing Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Chronic Inflammatory Response Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Cellular Protein Modification Process Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway B-1 B Cell Homeostasis Intracellular Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Cellular Macromolecule Catabolic Process Protein Localization To Cell Junction Protein K6-linked Ubiquitination Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Tolerance Induction Regulation Of Hepatocyte Proliferation Protein K11-linked Deubiquitination
Tagcloud ?		antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 trim trim6 tripartite ubiquitin unanchored unrecognized	amplifying bona brat depends exit fide ht2a lin41 mei named ncl1 nhl p26 perturb phenotypes preferred progenitor reconstituted repeat ring subfamily suppress suppressive transit tripartite ubch5a ubiquitinate ubiquitination
Tagcloud (Difference) ?		antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 trim6 ubiquitin unanchored unrecognized	amplifying bona brat depends exit fide ht2a lin41 mei named ncl1 nhl p26 perturb phenotypes preferred progenitor reconstituted repeat ring subfamily suppress suppressive transit ubch5a ubiquitinate ubiquitination
Tagcloud (Intersection) ?		trim tripartite