NRG1 and IKZF4

Number of citations of the paper that reports this interaction (PMID 15494726)
44

Data Source:
HPRD (in vivo, in vitro)

		NRG1	IKZF4
Gene Name		neuregulin 1	IKAROS family zinc finger 4 (Eos)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Axon Neuromuscular Junction	Nucleus
	Molecular Function	Transcription Cofactor Activity Receptor Binding Cytokine Activity ErbB-2 Class Receptor Binding Protein Binding Growth Factor Activity Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding ErbB-3 Class Receptor Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	MAPK Cascade Cell Morphogenesis Cardiac Conduction System Development Ventricular Trabecula Myocardium Morphogenesis Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Synapse Assembly Peripheral Nervous System Development Locomotory Behavior Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Cell Migration Glial Cell Fate Commitment Positive Regulation Of Cell Growth Mammary Gland Development Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway ERBB Signaling Pathway Wound Healing Negative Regulation Of Protein Catabolic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Cellular Protein Complex Disassembly Innate Immune Response Neurotransmitter Receptor Metabolic Process Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Fate Commitment Negative Regulation Of Secretion Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Endocardial Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143) Dialysis-related mortality ( 21546767) Hip geometry ( 17903296) Hirschsprung's disease ( 19196962) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906)	Alopecia areata ( 20596022) Asthma ( 21804548) Type 1 diabetes ( 18198356) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 22561518)
Protein-Protein Interactions		7 interactors: ADAM19 EGF ERBB2 ERBB3 ERBB4 IKZF4 LIMK1	12 interactors: CHD4 FHL2 FOXP3 HDAC2 IKZF1 IKZF2 IKZF3 IKZF5 NFKBIA NRG1 SIN3A SIN3B
Entrez ID		3084	64375
HPRD ID		00802	05874
Ensembl ID		ENSG00000157168	ENSG00000123411
Uniprot IDs		A6MW55 A6MW56 B0FWZ3 B0FYA7 B0FYA8 B0FYA9 B7Z1D7 B7Z1E3 Q02297 Q6PK61 Q7RTW3 Q7RTW5	G5E9S4 Q9H2S9
PDB IDs		1HAE 1HAF 1HRE 1HRF 3U7U	2MA7
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Innate Immune Response Cardiovascular System Development Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Kinase Activity Heart Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Immune Response Regulation Of Immune System Process Protein Phosphorylation Positive Regulation Of Transferase Activity Defense Response Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Phosphatidylinositol 3-kinase Signaling Regulation Of Peptidyl-tyrosine Phosphorylation Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Growth Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Phosphorylation Phosphorylation Signal Transduction By Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Immune System Process Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Tyrosine Kinase Activity	Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Chromatin Modification Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cardiac Muscle Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Histone Deacetylation Nucleobase-containing Compound Metabolic Process Protein Deacetylation Positive Regulation Of Cellular Biosynthetic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Striated Muscle Tissue Development Muscle Tissue Development Regulation Of Immune System Process Cardiac Muscle Cell Differentiation Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cardiocyte Differentiation Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Histone Acetylation Negative Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process
Tagcloud ?		appreciated cardiac cardiomyocyte cardiomyocytes cardiomyopathy chamber conscious contractility dilatation dilated dilation echocardiography ecs ejection erbb fractional hearts isoproterenol mechanistically neuregulin normalization normalized paracrine pecam proper shortening systolic tightly
Tagcloud (Difference) ?		appreciated cardiac cardiomyocyte cardiomyocytes cardiomyopathy chamber conscious contractility dilatation dilated dilation echocardiography ecs ejection erbb fractional hearts isoproterenol mechanistically neuregulin normalization normalized paracrine pecam proper shortening systolic tightly
Tagcloud (Intersection) ?