ZNRD1 and NONO

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZNRD1	NONO
Gene Name		zinc ribbon domain containing 1	non-POU domain containing, octamer-binding
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm DNA-directed RNA Polymerase I Complex	Nucleus Nucleoplasm Nucleolus Membrane Nuclear Matrix Nuclear Speck Paraspeckles
	Molecular Function	RNA Polymerase I Activity Nucleic Acid Binding Zinc Ion Binding	Nucleotide Binding Core Promoter Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	DNA Repair DNA Recombination Transcription, DNA-templated MRNA Processing Circadian Rhythm RNA Splicing Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS		AIDS progression ( 19115949) HIV-1 control ( 20041166)
Protein-Protein Interactions		15 interactors: APOA1 ATXN2 CIC DUSP1 FHL3 GFI1B GPR20 HAX1 IL15 IVNS1ABP NONO SACS SERPINA3 UBE2I ZNF593	35 interactors: APBB1 AR C11orf68 CA2 DDX6 ERG EWSR1 FXR2 HIST3H3 IL7R IRAK3 LMO4 MAD1L1 NUPR1 ORC5 PIN1 PLEKHF2 POLR2A PPP1CA PPP1CB PPP1CC PRKAA2 PRPF40A PSPC1 PTBP1 SFPQ SMARCB1 SMARCC1 SMARCD1 SPI1 SYNPO TCERG1 WBP4 YLPM1 ZNRD1
Entrez ID		30834	4841
HPRD ID		09601	02098
Ensembl ID		ENSG00000066379	ENSG00000147140
Uniprot IDs		Q2L6J2 Q9P1U0	Q15233
PDB IDs			3SDE
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Intracellular Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Extrathymic T Cell Selection Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of SUMO Transferase Activity Regulation Of Signal Transduction Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Interleukin-1 Beta Secretion Regulation Of Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import NK T Cell Proliferation Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Interleukin-1 Secretion Alpha-beta T Cell Proliferation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Protein Phosphorylation Skeletal Muscle Atrophy High-density Lipoprotein Particle Clearance Negative Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Natural Killer Cell Proliferation Striated Muscle Atrophy Protein Oxidation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Gene Expression Regulation Of Natural Killer Cell Proliferation Muscle Atrophy Negative Regulation Of Cytokine Secretion Involved In Immune Response Negative Regulation Of Heterotypic Cell-cell Adhesion High-density Lipoprotein Particle Assembly Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Component Organization Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Regulation Of Gene Expression RNA Metabolic Process Gene Expression Regulation Of Circadian Rhythm Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Nucleosome Disassembly Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Rhythmic Process Photoperiodism Entrainment Of Circadian Clock Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Acylglycerol Catabolic Process Cell Cycle Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Chromatin Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Glycogen Catabolic Process Energy Reserve Metabolic Process Chromatin Organization Chromosome Organization Biosynthetic Process Regulation Of Cellular Process Glycogen Metabolic Process MRNA Metabolic Process RNA Splicing Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Generation Of Precursor Metabolites And Energy Transcription From RNA Polymerase II Promoter Circadian Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Cellular Component Organization Polysaccharide Metabolic Process
Tagcloud ?		acceleration angiogenesis arrest block cdk2 cdk4 cip1 controlling cytostatic densities dephosphorylation differentially fragmentary gastric instability kip1 microarray microvessel mkn28 p27 pivotal prb precise ribbon sense skp2 suppressed waf1 zinc	acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms p54nrb pde pde11a pde2a pde3a pde3b pde4a pde4d phosphodiesterase select splicing xrn2
Tagcloud (Difference) ?		acceleration angiogenesis arrest block cdk2 cdk4 cip1 controlling cytostatic densities dephosphorylation differentially fragmentary gastric instability kip1 microarray microvessel mkn28 p27 pivotal prb precise ribbon sense skp2 suppressed waf1 zinc	acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms p54nrb pde pde11a pde2a pde3a pde3b pde4a pde4d phosphodiesterase select splicing xrn2
Tagcloud (Intersection) ?