HGFAC and SPINT2

Number of citations of the paper that reports this interaction (PMID 9346890)
16

Data Source:
HPRD (in vivo, in vitro)

		HGFAC	SPINT2
Gene Name		HGF activator	serine peptidase inhibitor, Kunitz type, 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Cytoplasm Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis	Movement Of Cell Or Subcellular Component Negative Regulation Of Endopeptidase Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: F2 HGF KLKB1 SPINT1 SPINT2	6 interactors: APP CTSB HGFAC ITIH2 ITIH3 SUMO4
Entrez ID		3083	10653
HPRD ID		05184	05495
Ensembl ID		ENSG00000109758	ENSG00000167642
Uniprot IDs		D6RAR4 Q04756	O43291
PDB IDs		1YBW 1YC0 2R0K 2R0L 2WUB 2WUC 3K2U
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Processing Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Fibrinolysis Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Fibrinolysis Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity Negative Regulation Of Blood Coagulation Blood Coagulation Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Body Fluid Levels Regulation Of Phosphatidylinositol 3-kinase Signaling Wound Healing Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Wounding Negative Regulation Of Cellular Metabolic Process Regulation Of Wound Healing Negative Regulation Of Catalytic Activity Factor XII Activation Protein Activation Cascade Platelet Activation Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Myoblast Proliferation Positive Regulation Of Fibrinolysis Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Plasminogen Activation Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Myelination Plasma Kallikrein-kinin Cascade Branching Involved In Labyrinthine Layer Morphogenesis Negative Regulation Of Fibrinolysis Positive Regulation Of Neuron Projection Regeneration Movement Of Cell Or Subcellular Component Extracellular Matrix Organization	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Hyaluronan Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Synaptic Growth At Neuromuscular Junction Negative Regulation Of Catalytic Activity Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Protein Metabolic Process Glycosaminoglycan Metabolic Process Negative Regulation Of Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Catalytic Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Cellular Response To Thyroid Hormone Stimulus Extracellular Matrix Organization Extracellular Structure Organization Response To Thyroid Hormone Decidualization Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior
Tagcloud ?		ascertain biovu chance clinician cngb3 compelling convulsions emr f5 gpr98 homozygotes inferred inheritance macular maf mendelian nssnp nssnps omim permuted platforms refine rs13157270 rs16844401 rs3735972 rs6031 synonymous twleve vanderbilt	adhesion cd49b cd49d cd49e clonal defective downregulated dysfunctional hematopoiesis hematopoietic hepatocyte herein hgf hsc ineffective kunitz microenvironment msc mscs niche onto pathophysiology progenitors renewal sdf silenced stromal supporting underexpression
Tagcloud (Difference) ?		ascertain biovu chance clinician cngb3 compelling convulsions emr f5 gpr98 homozygotes inferred inheritance macular maf mendelian nssnp nssnps omim permuted platforms refine rs13157270 rs16844401 rs3735972 rs6031 synonymous twleve vanderbilt	adhesion cd49b cd49d cd49e clonal defective downregulated dysfunctional hematopoiesis hematopoietic hepatocyte herein hgf hsc ineffective kunitz microenvironment msc mscs niche onto pathophysiology progenitors renewal sdf silenced stromal supporting underexpression
Tagcloud (Intersection) ?