HGD and CLDN7

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HGD	CLDN7
Gene Name		homogentisate 1,2-dioxygenase	claudin 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Tight Junction Integral Component Of Membrane Basolateral Plasma Membrane Lateral Plasma Membrane
	Molecular Function	Homogentisate 1,2-dioxygenase Activity Metal Ion Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	L-phenylalanine Catabolic Process Tyrosine Catabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules
Pathways		Phenylalanine and tyrosine catabolism Metabolism of amino acids and derivatives	Cell junction organization Cell-cell junction organization Tight junction interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CLDN7 GIT2 PCDHGC3 TERF1	5 interactors: EPCAM HGD RHOXF2 SYNE4 TJP1
Entrez ID		3081	1366
HPRD ID		06315	07633
Ensembl ID		ENSG00000113924	ENSG00000181885
Uniprot IDs		Q93099	F5H496 O95471
PDB IDs		1EY2 1EYB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Telomere Maintenance Via Telomere Shortening Negative Regulation Of Telomere Maintenance Via Telomerase Replicative Cell Aging Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Microtubule Polymerization Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules RNA-dependent DNA Replication Behavioral Response To Pain Negative Regulation Of DNA Biosynthetic Process Regulation Of Microtubule Polymerization Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Telomere Maintenance Via Telomere Lengthening Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Response To Pain Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Regulation Of DNA Biosynthetic Process Spindle Checkpoint Negative Regulation Of DNA Replication Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of ARF GTPase Activity Cell Aging Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Cellular Protein Catabolic Process Telomere Maintenance Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Cell Adhesion Negative Regulation Of Chromosome Organization Multicellular Organismal Response To Stress Negative Regulation Of DNA Metabolic Process Regulation Of ARF Protein Signal Transduction	Cell-cell Signaling Involved In Cell-cell Junction Organization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Response To Magnetism Epithelium Development Tyrosine Catabolic Process Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Endothelial Intestinal Barrier Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Tyrosine Metabolic Process L-phenylalanine Catabolic Process L-phenylalanine Metabolic Process Establishment Of Monopolar Cell Polarity Negative Regulation Of Vascular Permeability Tissue Development Establishment Of Epithelial Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Epithelial Cell Differentiation Morphogenesis Of A Polarized Epithelium Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Of Endothelial Barrier Hippo Signaling Regulation Of Vascular Permeability Signal Transduction Involved In Regulation Of Gene Expression Blastocyst Formation Aromatic Amino Acid Family Metabolic Process Endothelial Cell Development
Tagcloud ?		91patients aberrations abnormalities assesses barrett brush carcinogenic combining complementary cytology dysplasia eac esophagus evaluates fish goes gold histopathological ihc inc indirectly lgd periodicals representative respect staging tp53 unreliable wiley	acta2 cdh1 cdkn1a cldn1 cldn4 ctnnb1 fn1 krt19 mapk1 mapk14 mapk3 mki67 mmp2 mmp9 muc5ac muc6 nes pdac pdacs ptgs2 rps6 rps6kb1 smad4 stains surprising synchronous tgfb1 tgfbr1 vim
Tagcloud (Difference) ?		91patients aberrations abnormalities assesses barrett brush carcinogenic combining complementary cytology dysplasia eac esophagus evaluates fish goes gold histopathological ihc inc indirectly lgd periodicals representative respect staging tp53 unreliable wiley	acta2 cdh1 cdkn1a cldn1 cldn4 ctnnb1 fn1 krt19 mapk1 mapk14 mapk3 mki67 mmp2 mmp9 muc5ac muc6 nes pdac pdacs ptgs2 rps6 rps6kb1 smad4 stains surprising synchronous tgfb1 tgfbr1 vim
Tagcloud (Intersection) ?