HBZ and UPF2

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		HBZ	UPF2
Gene Name		hemoglobin, zeta	UPF2 regulator of nonsense transcripts homolog (yeast)
Image
Gene Ontology Annotations	Cellular Component	Hemoglobin Complex Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Oxygen Transporter Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Oxygen Transport Erythrocyte Maturation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Gene Expression Organ Regeneration
Pathways			Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		15 interactors: APP DOCK8 FGFR3 HBB HBD HNRNPD IKBKG KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 NOTCH2NL SP1 UPF2	75 interactors: ABCF2 AGPAT1 ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 GLTSCR2 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MYB NDUFA7 NOB1 NOMO1 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SKIV2L2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		3050	26019
HPRD ID		00794	10405
Ensembl ID			ENSG00000151461
Uniprot IDs		P02008	Q9HAU5
PDB IDs		1JEB 3W4U	1UW4 2WJV
Enriched GO Terms of Interacting Partners?		Response To Wounding Blood Coagulation Hemostasis Oxygen Transport Regulation Of Body Fluid Levels Wound Healing Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Sequestering Of Nodal From Receptor Via Nodal Binding Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Memory T Cell Proliferation Negative Regulation Of Nodal Signaling Pathway Synaptic Growth At Neuromuscular Junction Positive Regulation Of Cellular Protein Metabolic Process Nitric Oxide Transport Collateral Sprouting In Absence Of Injury Cell Recognition RNA Metabolic Process Camera-type Eye Morphogenesis MRNA Metabolic Process Positive Regulation Of Protein Metabolic Process Immune System Process Notch Signaling Pathway Developmental Growth Involved In Morphogenesis Response To Stress Gene Expression Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Transcription, DNA-templated Liver Development Regulation Of Nitrogen Compound Metabolic Process Eye Morphogenesis Alveolar Secondary Septum Development Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Determination Of Left/right Asymmetry In Lateral Mesoderm Circadian Regulation Of Translation Regulation Of Nodal Signaling Pathway Axonogenesis Involved In Innervation Axon Choice Point Recognition RNA Catabolic Process Cell Activation Platelet Activation Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression	Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process Gene Expression Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Catabolic Process Histone MRNA Catabolic Process RRNA Processing Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Translational Initiation Viral Process Ribosome Biogenesis Biosynthetic Process Histone MRNA Metabolic Process Cellular Metabolic Process Translational Termination Protein Complex Disassembly Translational Elongation RNA Biosynthetic Process Ribonucleoprotein Complex Biogenesis Cellular Protein Complex Disassembly Viral Transcription NcRNA Metabolic Process SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Metabolic Process Establishment Of Protein Localization To Membrane Translation Protein Targeting To Membrane Nuclear MRNA Surveillance Protein Localization To Membrane
Tagcloud ?		acted antisense aph appreciate atl barbeau behave bzip coimmunoprecipitation differently doi halin htert htlv intriguing jun junb jund jvi landry larocque marriott nonpathogenic retroviruses seemingly solely switzer transactivation virol	achieves bridge cenp centromere centromeres counteracted decay delocalization dispensable ebs1 extragenic fission interphase massive mis16 mis18 mis19 mis20 missegregation pombe recruiting schizosaccharomyces segregation sense snf snf22 snf5 sol1 swi
Tagcloud (Difference) ?		acted antisense aph appreciate atl barbeau behave bzip coimmunoprecipitation differently doi halin htert htlv intriguing jun junb jund jvi landry larocque marriott nonpathogenic retroviruses seemingly solely switzer transactivation virol	achieves bridge cenp centromere centromeres counteracted decay delocalization dispensable ebs1 extragenic fission interphase massive mis16 mis18 mis19 mis20 missegregation pombe recruiting schizosaccharomyces segregation sense snf snf22 snf5 sol1 swi
Tagcloud (Intersection) ?