PYCR2 and CIC

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PYCR2	CIC
Gene Name		pyrroline-5-carboxylate reductase family, member 2	capicua transcriptional repressor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity	DNA Binding Chromatin Binding Protein Binding
	Biological Process	Oxidation-reduction Process L-proline Biosynthetic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Lung Alveolus Development
Pathways
Drugs		NADH L-Proline
Diseases
GWAS
Protein-Protein Interactions		3 interactors: APP CIC SKIL	13 interactors: ATXN1 CENPJ CSNK2B GABPB1 GTPBP3 NFYC PICK1 PLK1 PYCR2 SEC62 SETD2 TRIM22 ZNRD1
Entrez ID		29920	23152
HPRD ID		17939	10831
Ensembl ID		ENSG00000143811	ENSG00000079432
Uniprot IDs		Q96C36	Q96RK0
PDB IDs			4J2J 4J2L
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Regulation Of Transcription From RNA Polymerase II Promoter Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Metabolic Process Axon Choice Point Recognition Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Neuron Remodeling Protein Heterotrimerization Regulation Of Neuron Differentiation Organ Development Protein Homotrimerization Cellular Copper Ion Homeostasis RNA Metabolic Process Regulation Of Neurogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Copper Ion Homeostasis Suckling Behavior Negative Regulation Of Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Sexual Reproduction Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Cell Development Mating Behavior Lens Fiber Cell Differentiation Protein Trimerization Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell Cycle RNA Polyadenylation Neuron Recognition Blastocyst Formation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway System Development Reproduction Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Axon Cargo Transport Negative Regulation Of Nucleic Acid-templated Transcription	Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Histone H3-K36 Trimethylation RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Elongation Activation Of APC-Cdc20 Complex Activity Cellular Aromatic Compound Metabolic Process Centrosome Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Cell Migration Involved In Vasculogenesis Microtubule Organizing Center Organization Cellular Nitrogen Compound Metabolic Process G2/M Transition Of Mitotic Cell Cycle Polar Body Extrusion After Meiotic Divisions Cellular Metabolic Process Activation Of Anaphase-promoting Complex Activity Meiotic Cytokinesis L-proline Biosynthetic Process Posttranslational Protein Targeting To Membrane Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Activin Receptor Signaling Pathway DNA Methylation Involved In Embryo Development Adiponectin-activated Signaling Pathway Regulation Of MRNA Export From Nucleus Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Metaphase/anaphase Transition Of Mitotic Cell Cycle Histone H3-K36 Methylation Dendritic Spine Maintenance Regulation Of Metabolic Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Metabolic Process Tube Development Coronary Vasculature Morphogenesis Endothelial Tube Morphogenesis Gene Expression Regulation Of Centriole Replication Protein Localization To Chromatin Neuronal Ion Channel Clustering Mitotic Cell Cycle Regulation Of RNA Export From Nucleus Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Tagcloud ?		adipocyte biologically chick chicken chickens cutoff experimentally klf5 lpin1 luciferase map3k7 mettl14 microrna mir miranda mirna pck2 pdcd5 pstpip1 slc2a2 splenocytes tardbp tnfsf10 transcriptionally tumourigenesis ube2e3 ubiquitously utrs vertebrate	aetiology assumed bacteriuria catheterization clean complaints distress epq evaluations eysenck ghq intermittent inventory neurogenic neurotic neuroticism personality practised prescription psychometric spielberger stai thirds tolerability trait undergone unnecessary verify x1
Tagcloud (Difference) ?		adipocyte biologically chick chicken chickens cutoff experimentally klf5 lpin1 luciferase map3k7 mettl14 microrna mir miranda mirna pck2 pdcd5 pstpip1 slc2a2 splenocytes tardbp tnfsf10 transcriptionally tumourigenesis ube2e3 ubiquitously utrs vertebrate	aetiology assumed bacteriuria catheterization clean complaints distress epq evaluations eysenck ghq intermittent inventory neurogenic neurotic neuroticism personality practised prescription psychometric spielberger stai thirds tolerability trait undergone unnecessary verify x1
Tagcloud (Intersection) ?