HCFC2 and ASH2L

Number of citations of the paper that reports this interaction (PMID 15199122)
194

Data Source:
BioGRID (pull down, affinity chromatography technology)

		HCFC2	ASH2L
Gene Name		host cell factor C2	ash2 (absent, small, or homeotic)-like (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane	Nucleus Nucleoplasm Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	Transcription Coactivator Activity	DNA Binding Protein Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Viral Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Proliferation Hemopoiesis Response To Estrogen Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K4 Methylation
Pathways			Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Signaling by Wnt deactivation of the beta-catenin transactivating complex Chromatin modifying enzymes TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer
Drugs
Diseases
GWAS			Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		2 interactors: ASH2L KMT2A	22 interactors: BARD1 BRCA1 CHD8 CTNNB1 DPY30 EP300 HCFC2 HIST1H3A HIST3H3 KMT2A KMT2D MEN1 PPP1CC PRMT1 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 UNC119 WWP1 ZSCAN1
Entrez ID		29915	9070
HPRD ID		06393	05309
Ensembl ID			ENSG00000129691
Uniprot IDs		Q9Y5Z7	B4DPT1 F5H8F7 Q9UBL3
PDB IDs			3RSN 3S32 3TOJ
Enriched GO Terms of Interacting Partners?		Histone H3-K4 Methylation Histone Lysine Methylation Peptidyl-lysine Methylation Histone Methylation Protein Methylation Positive Regulation Of Cellular Response To Drug Peptidyl-lysine Modification Regulation Of Histone H3-K14 Acetylation Regulation Of Cellular Response To Drug Histone Modification Methylation Regulation Of Response To Drug Chromatin Modification Hemopoiesis Immune System Development Chromatin Organization Regulation Of Histone H3-K9 Acetylation Histone H3-K4 Trimethylation Histone H4-K16 Acetylation Positive Regulation Of Histone H3-K4 Methylation Transcription From RNA Polymerase II Promoter Peptidyl-amino Acid Modification Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Histone H3-K4 Methylation Peptidyl-lysine Trimethylation Embryonic Hemopoiesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Histone Methylation Regulation Of Cell Proliferation Regulation Of Histone Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Histone H4 Acetylation Regulation Of Histone Methylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transporter Activity DNA Methylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Histone Modification Circadian Regulation Of Gene Expression DNA Modification Immune System Process Transcription, DNA-templated Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation RNA Biosynthetic Process Internal Protein Amino Acid Acetylation Regulation Of Histone Modification	Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Histone Modification Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin Organization Negative Regulation Of Biosynthetic Process Chromosome Organization Positive Regulation Of Histone Methylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Histone Methylation Regulation Of Histone Modification Positive Regulation Of Transcription, DNA-templated Regulation Of Histone Methylation Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Signal Transduction Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Macromolecule Biosynthetic Process Embryo Development Positive Regulation Of Gene Expression Protein Methylation Negative Regulation Of Signaling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Histone H3-K4 Methylation Nucleobase-containing Compound Metabolic Process Chromatin Modification Regulation Of Chromosome Organization Histone Modification Heterocycle Metabolic Process
Tagcloud ?			acidic allosterically box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wdr5 wrad
Tagcloud (Difference) ?			acidic allosterically box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wdr5 wrad
Tagcloud (Intersection) ?