USP25 and ACTA1

Number of citations of the paper that reports this interaction (PMID 16501887)
5

Data Source:
BioGRID (pull down)

		USP25	ACTA1
Gene Name		ubiquitin specific peptidase 25	actin, alpha 1, skeletal muscle
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity SUMO Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Cellular Protein Modification Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS		Panic disorder ( 19165232) Parkinson's disease ( 21738487)
Protein-Protein Interactions		14 interactors: ACTA1 FLNC GAPDH MAGEB4 MT2A RAD23A SENP1 SKIL SUMO1 SUMO2 SYK UBC UBE2I ZNF426	107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		29761	58
HPRD ID		05296	00030
Ensembl ID		ENSG00000155313	ENSG00000143632
Uniprot IDs		Q9UHP3	P68133 Q5T8M7
PDB IDs			1T44
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Peptidyl-amino Acid Modification Peptidyl-lysine Modification Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Cytokine Regulation Of Cellular Protein Metabolic Process Innate Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Interferon-gamma Positive Regulation Of Cellular Protein Catabolic Process Response To Interferon-gamma Response To Organic Substance Viral Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Cytokine Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Muscle Fiber Development Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Defense Response Negative Regulation Of Biosynthetic Process Immune System Process Peptidyl-cysteine S-trans-nitrosylation Positive Regulation Of SUMO Transferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Metabolic Process JNK Cascade Skeletal Muscle Fiber Adaptation Beta Selection Positive Regulation Of Interleukin-3 Biosynthetic Process Cellular Response To Molecule Of Fungal Origin Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly
Tagcloud ?		chains cleaved cys178 cysteine deubiquitinated deubiquitinating deubiquitination dub emerged his607 histidine ifn interferon irf3 lost lysine mechanistically polyubiquitin potentiated proteases residue rig screen traf2 traf6 triggered tumornecrosis ubiquitination usps	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Difference) ?		chains cleaved cys178 cysteine deubiquitinated deubiquitinating deubiquitination dub emerged his607 histidine ifn interferon irf3 lost lysine mechanistically polyubiquitin potentiated proteases residue rig screen traf2 traf6 triggered tumornecrosis ubiquitination usps	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Intersection) ?