GTF2H2 and GTF2H5

Number of citations of the paper that reports this interaction (PMID 15220921)
66

Data Source:
HPRD (in vivo)

		GTF2H2	GTF2H5
Gene Name		general transcription factor IIH, polypeptide 2, 44kDa	general transcription factor IIH, polypeptide 5
Image
Gene Ontology Annotations	Cellular Component	Core TFIIH Complex Nucleoplasm Holo TFIIH Complex	Core TFIIH Complex Nucleolus
	Molecular Function	Nucleic Acid Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity Translation Factor Activity, Nucleic Acid Binding Zinc Ion Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Protein N-terminus Binding	RDNA Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal G-protein Coupled Receptor Internalization DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Translation Protein Phosphorylation Response To UV Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription	Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Regulation Of Transcription, DNA-templated Transcription Elongation From RNA Polymerase I Promoter RRNA Processing Cellular Response To Gamma Radiation
Pathways		RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: AR CDK7 ERCC2 ERCC3 ERCC8 GTF2H1 GTF2H3 GTF2H5 SRA1	3 interactors: CDK7 ERCC3 GTF2H2
Entrez ID		2966	404672
HPRD ID		03450	10581
Ensembl ID		ENSG00000145736	ENSG00000272047
Uniprot IDs		Q13888	Q6ZYL4
PDB IDs		1Z60	1YDL 2JNJ
Enriched GO Terms of Interacting Partners?		Transcription Elongation From RNA Polymerase I Promoter Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Damage Removal Termination Of RNA Polymerase I Transcription DNA-templated Transcription, Elongation Transcription Initiation From RNA Polymerase I Promoter 7-methylguanosine MRNA Capping 7-methylguanosine RNA Capping Positive Regulation Of Viral Transcription Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation DNA Repair DNA Catabolic Process Regulation Of Viral Process Cellular Response To DNA Damage Stimulus MRNA Processing Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic MRNA Metabolic Process DNA Metabolic Process RNA Processing Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Stress Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Viral Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Nucleotide-excision Repair, DNA Incision Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated	Nucleotide-excision Repair, DNA Damage Removal Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Nucleotide-excision Repair DNA Catabolic Process Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation MRNA Processing Aromatic Compound Catabolic Process MRNA Metabolic Process Viral Process RNA Processing DNA Repair Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Transcription From RNA Polymerase II Promoter DNA Metabolic Process Response To UV Nucleotide-excision Repair, DNA Duplex Unwinding Protein Phosphorylation Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Catabolic Process Phosphorylation Response To Light Stimulus Nucleotide-excision Repair, DNA Incision Transcription, DNA-templated RNA Biosynthetic Process Response To Radiation Positive Regulation Of Cellular Metabolic Process G-protein Coupled Receptor Internalization Phosphate-containing Compound Metabolic Process UV Protection
Tagcloud ?		acetylation bioflavonoid ccna2 ccnd1 cdkn1a chip crna ddx5 epigenetic esp estrogenic h4 immunoprecipitation involving luteolin mcf microarray modified ncoa3 ncor1 nras nrip1 pcna plk plk1 polr2a proliferative qpcr taf9	accompanies anova dynactin gadd45a invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Difference) ?		acetylation bioflavonoid ccna2 ccnd1 cdkn1a chip crna ddx5 epigenetic esp estrogenic h4 immunoprecipitation involving luteolin mcf microarray modified ncoa3 ncor1 nras nrip1 pcna plk plk1 polr2a proliferative qpcr taf9	accompanies anova dynactin gadd45a invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Intersection) ?