GSTA4 and C2orf50

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GSTA4	C2orf50
Gene Name		glutathione S-transferase alpha 4	chromosome 2 open reading frame 50
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Glutathione Transferase Activity Protein Homodimerization Activity
	Biological Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Small Molecule Metabolic Process Glutathione Derivative Biosynthetic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione
Diseases
GWAS			Metabolite levels (HVA/MHPG ratio) ( 23319000)
Protein-Protein Interactions		2 interactors: C2orf50 GSTA2	2 interactors: GSTA4 SPP1
Entrez ID		2941	130813
HPRD ID		06899	08051
Ensembl ID		ENSG00000170899	ENSG00000150873
Uniprot IDs		O15217 Q6P4G1	Q96LR7
PDB IDs		1GUL 1GUM 3IK7
Enriched GO Terms of Interacting Partners?		Glutathione Derivative Biosynthetic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Peptide Metabolic Process Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Sulfur Compound Metabolic Process	Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Positive Regulation Of Bone Resorption Regulation Of Axon Regeneration Glutathione Derivative Biosynthetic Process Positive Regulation Of Tissue Remodeling Response To Vitamin D Decidualization Regulation Of Bone Resorption Maternal Placenta Development Regulation Of Bone Remodeling Neutrophil Chemotaxis Neutrophil Migration Granulocyte Chemotaxis Negative Regulation Of Axonogenesis Regulation Of Tissue Remodeling Glutathione Metabolic Process Biomineral Tissue Development Embryo Implantation Maternal Process Involved In Female Pregnancy Negative Regulation Of Developmental Growth Extracellular Matrix Disassembly Negative Regulation Of Cell Morphogenesis Involved In Differentiation Leukocyte Chemotaxis Response To Vitamin Negative Regulation Of Neuron Projection Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Size Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Osteoblast Differentiation Negative Regulation Of Cell Projection Organization Response To Xenobiotic Stimulus Peptide Metabolic Process Negative Regulation Of Cell Growth Regulation Of Axonogenesis Cell Chemotaxis Negative Regulation Of Neuron Differentiation Placenta Development Regulation Of Cell-substrate Adhesion Response To Nutrient
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