GSPT1 and GSPT2

Number of citations of the paper that reports this interaction (PMID 9712840)
25

Data Source:
HPRD (in vivo, two hybrid)

		GSPT1	GSPT2
Gene Name		G1 to S phase transition 1	G1 to S phase transition 2
Image
Gene Ontology Annotations	Cellular Component	Intracellular	Cytosol
	Molecular Function	Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding Poly(A) RNA Binding	GTPase Activity Protein Binding GTP Binding Poly(A) RNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translational Termination Protein Methylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Termination Cell Cycle Gene Expression Cellular Protein Metabolic Process
Pathways			Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nonsense-Mediated Decay (NMD) Translation Eukaryotic Translation Termination Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ATXN1 BIRC2 BIRC3 CDKN2A ETF1 GSPT2 HINFP PABPC1 PIK3R1 XIAP	5 interactors: APP ETF1 GSPT1 PABPC1 UPF1
Entrez ID		2935	23708
HPRD ID		00753	02334
Ensembl ID		ENSG00000103342	ENSG00000189369
Uniprot IDs		B2RCT6 P15170 Q7KZX8	Q8IYD1
PDB IDs		3E1Y 3KUI	3KUJ
Enriched GO Terms of Interacting Partners?		Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Ubiquitination Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Necroptotic Process Negative Regulation Of Necrotic Cell Death Regulation Of Endopeptidase Activity Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Regulation Of Peptidase Activity Positive Regulation Of Protein Ubiquitination Apoptotic Process Posttranscriptional Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process Programmed Cell Death Regulation Of Necrotic Cell Death MRNA Catabolic Process Cell Death Death Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process RNA Catabolic Process Necroptotic Process Protein Ubiquitination RNA Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Signal Transduction Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Immune System Process Negative Regulation Of Cell-matrix Adhesion Gene Expression Regulation Of Proteolysis Regulation Of Innate Immune Response Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Programmed Necrotic Cell Death Cellular Macromolecule Biosynthetic Process Necrotic Cell Death Negative Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Regulation Of Translation Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Regulation Of Translational Termination Cellular Macromolecule Catabolic Process MRNA Polyadenylation RNA Polyadenylation RNA Metabolic Process Gene Expression MRNA 3'-end Processing Catabolic Process RNA 3'-end Processing Translation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Complex Disassembly Nucleobase-containing Compound Metabolic Process Translational Termination Regulation Of Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Synaptic Growth At Neuromuscular Junction Cellular Nitrogen Compound Metabolic Process Protein Methylation Cellular Protein Complex Disassembly Collateral Sprouting In Absence Of Injury Nitrogen Compound Metabolic Process Protein Complex Disassembly Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Histone MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Dosage Compensation By Inactivation Of X Chromosome Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Dosage Compensation Methylation MRNA Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Cellular Copper Ion Homeostasis
Tagcloud ?		abnormally blasts bmmncs chest clustered customized ddit3 dimerization ets etv1 helicase mad max microarray pathogenetic raeb raebt refractory ribs rnahp rtc semiquantitative seventeen tensin thbs1 thrombocytopenia thrombospondin transcriptome try
Tagcloud (Difference) ?		abnormally blasts bmmncs chest clustered customized ddit3 dimerization ets etv1 helicase mad max microarray pathogenetic raeb raebt refractory ribs rnahp rtc semiquantitative seventeen tensin thbs1 thrombocytopenia thrombospondin transcriptome try
Tagcloud (Intersection) ?