TBK1 and NFKBIA

Number of citations of the paper that reports this interaction (PMID 8601309)
185

Data Source:
HPRD (in vivo, in vitro)

		TBK1	NFKBIA
Gene Name		TANK-binding kinase 1	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Endosome Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane I-kappaB/NF-kappaB Complex
	Molecular Function	Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphoprotein Binding	Protein Binding Transcription Factor Binding Nuclear Localization Sequence Binding Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Negative Regulation Of Gene Expression Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Peptidyl-serine Phosphorylation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Gram-positive Bacterium Defense Response To Virus	Protein Import Into Nucleus, Translocation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Viral Process Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Cell Proliferation Regulation Of NF-kappaB Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Apoptotic Process Response To Exogenous DsRNA Negative Regulation Of DNA Binding Innate Immune Response Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cold Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Pathways		Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Regulation of innate immune responses to cytosolic DNA IRF3 mediated activation of type 1 IFN Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade STING mediated induction of host immune responses TRAF6 mediated IRF7 activation IRF3-mediated induction of type I IFN STAT6-mediated induction of chemokines Innate Immune System	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Activation of NF-kappaB in B cells Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS			Psoriasis ( 20953189 20953190)
Protein-Protein Interactions		38 interactors: AGO2 APP ATG9A AZI2 CALCOCO2 CDC37 CDC42BPG HSP90AA1 HSP90AB1 IKBKB IKBKE IKBKG IRF3 IRF5 IRF7 MAVS MBP MIB1 MIB2 MTPAP NCK1 NEDD4 NFKBIA OPTN PELI1 PROS1 RELA SIKE1 STX11 TANK TICAM1 TRAF2 TRAF3 TRAF3IP2 TRIM27 TXLNA TXLNG XIAP	87 interactors: ABL1 ARRB1 ARRB2 ATF4 AURKA BARD1 BTRC CAPN1 CAPN2 CD7 CDC34 CHUK COMMD1 COPS8 CSNK2A1 CUL1 DNAJA3 DYNLL1 EIF2AK2 FBXW11 G3BP2 HDAC1 HDAC3 HNRNPA1 HOXA9 HOXB7 HSPB1 IKBKAP IKBKB IKBKE IKBKG IKZF4 ITPK1 JAK2 LCK LYL1 MAP3K1 MAP3K14 MAP3K2 MAP3K3 MCM5 MCM7 MED19 NCOR2 NEDD9 NFKB1 NFKB2 NFKBIB NKIRAS1 NKIRAS2 PIK3R1 PIR POLR2C POM121 PRKCA PRKCI PSMA2 PTPN1 PTPN13 RBX1 REL RELA RNF7 RPS6KA1 RPS6KA3 RWDD3 SKP1 SLC25A4 SLC25A5 SRC ST7 SUMO1 SUMO2 SUMO3 SUMO4 TBK1 TNF TNFSF11 TP53 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2L3 VCP ZNF212
Entrez ID		29110	4792
HPRD ID		05322	01235
Ensembl ID		ENSG00000183735	ENSG00000100906
Uniprot IDs		Q9UHD2	P25963
PDB IDs		4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ	1IKN 1NFI
Enriched GO Terms of Interacting Partners?		Innate Immune Response Immune Response Defense Response Immune System Process Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Response To Stress Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cytokine Production Positive Regulation Of Type I Interferon Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Communication Positive Regulation Of Immune System Process Positive Regulation Of Cytokine Production Intracellular Receptor Signaling Pathway Signaling Response To Stimulus I-kappaB Kinase/NF-kappaB Signaling Signal Transduction Regulation Of Interferon-beta Production Response To Other Organism Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Biotic Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Interferon-beta Production Response To External Stimulus Toll-like Receptor 9 Signaling Pathway Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Response To DsRNA Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Signaling	Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Signal Transduction Cellular Response To Stimulus Negative Regulation Of Cell Death Cellular Metabolic Process Toll-like Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Cellular Process Signaling Intracellular Signal Transduction Immune Response Negative Regulation Of Programmed Cell Death Cell Communication Regulation Of Cell Death Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Activation Of Innate Immune Response Innate Immune Response Negative Regulation Of Apoptotic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Immune System Process I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Gene Expression Response To Growth Factor Regulation Of Cytokine Production Response To Stress Regulation Of Nitrogen Compound Metabolic Process Regulation Of Immune Response
Tagcloud ?		associates bax besides characterizes chemokines cytochrome cytosol dispensable hsp90 ikki immediate indispensable initiates initiating irf3 leakage mitochondrion onto outer recruits relocation restrain restrict sacrifice sendai sev tom70 triggers uncovers	1alpha advance aggressiveness biopsies cd31 collectively december dehydrogenase demands deregulated diffuse doi enhancing enzymes gapdh glyceraldehyde glycolytic hif hodgkin inactive leu lymphoma lymphomagenesis online promote publication traf2 transformed vascularization
Tagcloud (Difference) ?		associates bax besides characterizes chemokines cytochrome cytosol dispensable hsp90 ikki immediate indispensable initiates initiating irf3 leakage mitochondrion onto outer recruits relocation restrain restrict sacrifice sendai sev tom70 triggers uncovers	1alpha advance aggressiveness biopsies cd31 collectively december dehydrogenase demands deregulated diffuse doi enhancing enzymes gapdh glyceraldehyde glycolytic hif hodgkin inactive leu lymphoma lymphomagenesis online promote publication traf2 transformed vascularization
Tagcloud (Intersection) ?