NXT1 and RAN

Number of citations of the paper that reports this interaction (PMID 10567585)
32

Data Source:
HPRD (in vitro, in vivo)

		NXT1	RAN
Gene Name		nuclear transport factor 2-like export factor 1	RAN, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Nuclear Pore Cytoplasm Nuclear Speck	Chromatin Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Melanosome Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Ran GTPase Binding	Chromatin Binding Transcription Coactivator Activity GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Poly(A) RNA Binding Androgen Receptor Binding
	Biological Process	RNA Export From Nucleus Protein Export From Nucleus	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus DNA Metabolic Process Protein Import Into Nucleus Protein Export From Nucleus Mitotic Spindle Organization Mitotic Nuclear Division Signal Transduction Small GTPase Mediated Signal Transduction Spermatid Development Gene Expression Viral Process Viral Life Cycle Actin Cytoskeleton Organization Androgen Receptor Signaling Pathway Positive Regulation Of Protein Binding Cellular Protein Complex Localization Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Cell Division Intracellular Transport Of Virus
Pathways			Transcriptional regulation by small RNAs Metabolism of lipids and lipoproteins Nuclear import of Rev protein HIV Infection Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Host Interactions of HIV factors MicroRNA (miRNA) biogenesis Influenza Infection Interactions of Rev with host cellular proteins Late Phase of HIV Life Cycle Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Export of Viral Ribonucleoproteins from Nucleus HIV Life Cycle Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: DDOST NXF1 NXF2 NXF3 PAXIP1 RAN STAU1 XPO1	55 interactors: ABL1 ADRB2 AR ASAP2 BCAR1 BMPR1B CSE1L EP300 GADD45G GIT1 IPO11 IPO13 IPO5 IPO7 KIAA1377 KPNA2 KPNB1 MBP MSL1 NEK9 NR3C1 NSMF NUP153 NUP50 NUPR1 NUTF2 NXF1 NXT1 PAK4 PTMA RANBP1 RANBP10 RANBP2 RANBP3 RANBP9 RANGAP1 RANGRF RCC1 RGPD5 RPL7 SMAD1 SMAD2 SMARCB1 SMURF2 SNUPN SPAG8 SSRP1 TGFBR1 TNPO1 TNPO2 XPO1 XPO4 XPO5 XPO7 XPOT
Entrez ID		29107	5901
HPRD ID		16159	03109
Ensembl ID		ENSG00000132661
Uniprot IDs		Q9UKK6	B4DV51 P62826
PDB IDs		1JKG 1JN5	1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4
Enriched GO Terms of Interacting Partners?		Nuclear Export RNA Localization Nucleocytoplasmic Transport Nuclear Transport Cytoplasmic Transport MRNA Transport RNA Transport Ribosomal Small Subunit Export From Nucleus Cellular Localization MRNA Export From Nucleus RNA Export From Nucleus Intracellular Transport Ribosomal Large Subunit Export From Nucleus Ribosomal Subunit Export From Nucleus Poly(A)+ MRNA Export From Nucleus Establishment Of Localization In Cell Gene Expression Intracellular Transport Of Virus Protein Export From Nucleus Positive Regulation Of Histone H3-K36 Methylation Protein Localization To Organelle Viral Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Protein Localization To Nucleus Transport Ribosome Biogenesis Viral Life Cycle Intracellular Protein Transport Chorion Development Intracellular MRNA Localization Cellular Protein Complex Localization Ribonucleoprotein Complex Biogenesis Establishment Of Organelle Localization Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Histone H3-K4 Methylation Establishment Of Protein Localization To Organelle Positive Regulation Of DNA-templated Transcription, Initiation Protein Complex Localization Positive Regulation Of Histone Acetylation Positive Regulation Of Viral Genome Replication Regulation Of DNA-templated Transcription, Initiation Regulation Of Histone H3-K4 Methylation Cellular Protein Localization Organelle Localization Protein Targeting Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Isotype Switching Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Acetylation Protein Transport	Nucleocytoplasmic Transport Nuclear Transport Cytoplasmic Transport Intracellular Transport Protein Transport Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Protein Transport Nuclear Import Protein Localization Cellular Localization Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cellular Protein Localization Protein Import Establishment Of Protein Localization To Organelle RNA Transport RNA Localization Protein Localization To Organelle Protein Targeting Protein Export From Nucleus Nuclear Export Transport Ribosomal Protein Import Into Nucleus Positive Regulation Of Ran GTPase Activity Viral Life Cycle MRNA Transport Cellular Response To Organic Substance Mitotic Cell Cycle Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly NLS-bearing Protein Import Into Nucleus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Organic Substance Regulation Of Nucleocytoplasmic Transport Cell Cycle Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Process Nuclear Envelope Organization Mitotic Cell Cycle Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Export From Nucleus Intracellular Transport Of Virus Regulation Of Intracellular Transport Cellular Response To Transforming Growth Factor Beta Stimulus Viral Transcription
Tagcloud ?			5a accessible actually arginine bandshift bi cargo characterised directional dissociated export exports gtpase heterodimer import imported importin localisation masks multimeric nes nls nucleoplasm overlaps rab rev rip shuttle unspliced
Tagcloud (Difference) ?			5a accessible actually arginine bandshift bi cargo characterised directional dissociated export exports gtpase heterodimer import imported importin localisation masks multimeric nes nls nucleoplasm overlaps rab rev rip shuttle unspliced
Tagcloud (Intersection) ?