GRIK5 and MLF1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GRIK5	MLF1
Gene Name		glutamate receptor, ionotropic, kainate 5	myeloid leukemia factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Postsynaptic Density Cell Junction Dendrite Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity SH3 Domain Binding PDZ Domain Binding Identical Protein Binding	DNA Binding Protein Binding Protein Domain Specific Binding
	Biological Process	Protein Retention In ER Lumen Synaptic Transmission Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Establishment Of Localization In Cell Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To Glucose Stimulus	Myeloid Progenitor Cell Differentiation Transcription, DNA-templated Cell Cycle Arrest
Pathways		Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs		L-Glutamic Acid
Diseases
GWAS		Bipolar disorder ( 21771265)
Protein-Protein Interactions		8 interactors: DLG4 GOLM1 GPAA1 GRID2 GRIK2 GRIK3 LRSAM1 MLF1	6 interactors: CENPU COPS3 GRIK5 MAGEA11 NRBP1 YWHAZ
Entrez ID		2901	4291
HPRD ID		02614	03239
Ensembl ID		ENSG00000105737	ENSG00000178053
Uniprot IDs		Q16478	B2RD48 P58340 Q2TLE4 Q5HYH4
PDB IDs			3UAL 3UBW
Enriched GO Terms of Interacting Partners?		Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Protein Retention In ER Lumen Maintenance Of Protein Localization In Endoplasmic Reticulum Membrane Depolarization Negative Regulation Of Synaptic Transmission, Glutamatergic Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Endocytosis Regulation Of Synaptic Transmission Receptor Clustering Cell-cell Signaling Regulation Of Neuronal Synaptic Plasticity Protein Localization Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Vesicle-mediated Transport Ubiquitin-dependent Endocytosis Positive Regulation Of Synaptic Transmission Cellular Protein Localization Protein Localization To Endoplasmic Reticulum Neuromuscular Process Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Synaptic Plasticity Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Endocytosis Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Vesicle Organization Maintenance Of Apical/basal Cell Polarity Membrane Organization Regulation Of Cellular Component Organization Receptor Localization To Synapse Regulation Of Neuron Apoptotic Process Negative Regulation Of Receptor Internalization Viral Budding Myeloid Progenitor Cell Differentiation Locomotory Exploration Behavior Dendritic Spine Morphogenesis Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Neuron Death Synaptic Vesicle Maturation	Golgi Reassembly Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Histamine Secretion By Mast Cell Establishment Of Golgi Localization Golgi Inheritance Cullin Deneddylation Histamine Secretion Protein Retention In ER Lumen Protein Deneddylation Maintenance Of Protein Localization In Endoplasmic Reticulum Histamine Transport Golgi Localization Mast Cell Degranulation Protein Localization To Organelle Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Mast Cell Mediated Immunity Establishment Of Localization In Cell CENP-A Containing Nucleosome Assembly Lysosome Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Mast Cell Activation Positive Regulation Of Cell Death Histone Exchange Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis DNA Replication-independent Nucleosome Assembly Leukocyte Degranulation Cytoplasmic Transport Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Transport Cellular Localization Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Regulated Secretory Pathway Chordate Embryonic Development Centromere Complex Assembly Embryo Development Ending In Birth Or Egg Hatching
Tagcloud ?		abuse bdkrb2 bipolar compulsive confer defines difficulty disorders eating genetics ghrh hint ionotropic kainate neurodevelopment neurotransmission obsessive odd panic preb prolactin psychiatric psychotic releasing rs945032 snps substance susceptibility synonymous	akt1 akt2 aurka axon card11 deregulated exclusive exome fgfr2 grouping hook3 integrative massively men1 mutually nets neuroendocrine nono pdgfr preponderance provisional recurrently si smad smad1 snvs therapeutically transitions vhl
Tagcloud (Difference) ?		abuse bdkrb2 bipolar compulsive confer defines difficulty disorders eating genetics ghrh hint ionotropic kainate neurodevelopment neurotransmission obsessive odd panic preb prolactin psychiatric psychotic releasing rs945032 snps substance susceptibility synonymous	akt1 akt2 aurka axon card11 deregulated exclusive exome fgfr2 grouping hook3 integrative massively men1 mutually nets neuroendocrine nono pdgfr preponderance provisional recurrently si smad smad1 snvs therapeutically transitions vhl
Tagcloud (Intersection) ?