ABR and ERBB2IP

Number of citations of the paper that reports this interaction (PMID 15123239)
9

Data Source:
BioGRID (unspecified method)

		ABR	ERBB2IP
Gene Name		active BCR-related	erbb2 interacting protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Basement Membrane Nucleus Nucleoplasm Cytoplasm Plasma Membrane Basal Plasma Membrane Cell Junction Hemidesmosome Nuclear Membrane
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Rac GTPase Activator Activity	ErbB-2 Class Receptor Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Brain Development Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Response To Lipopolysaccharide Positive Regulation Of Rac GTPase Activity Inner Ear Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Neutrophil Degranulation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Protein Targeting Cell Cycle Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Growth Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling	Signaling by ERBB2
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ADRA1A APP ECT2 ERBB2IP LNX1	62 interactors: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 NOD2 NR2E1 PICK1 PKP4 RAF1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9
Entrez ID		29	55914
HPRD ID		02649	06090
Ensembl ID		ENSG00000159842	ENSG00000112851
Uniprot IDs		B7Z2X0 B7Z683 B7Z7Z1 Q12979 Q6ZT60	B4DIP2 Q96RT1
PDB IDs			1MFG 1MFL 1N7T 2H3L 2QBW 3CH8
Enriched GO Terms of Interacting Partners?		Cell Growth Growth Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Basal Protein Localization Synaptic Growth At Neuromuscular Junction Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Collateral Sprouting In Absence Of Injury Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Apoptotic Process Programmed Cell Death Positive Regulation Of Hydrolase Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Pilomotor Reflex Cell Death Death Positive Regulation Of Cell Cycle Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Protein Homooligomerization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Axon Choice Point Recognition Micturition Positive Regulation Of Cardiac Muscle Contraction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle Cellular Calcium Ion Homeostasis Regulation Of Phosphorylation Calcium Ion Homeostasis Regulation Of The Force Of Heart Contraction By Chemical Signal Neuron Remodeling Positive Regulation Of Action Potential Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Heart Rate Regulation Of Phosphorus Metabolic Process Positive Regulation Of Striated Muscle Contraction Intracellular Transport Positive Regulation Of Catalytic Activity Positive Regulation Of Systemic Arterial Blood Pressure Activation Of Rac GTPase Activity Cellular Metal Ion Homeostasis Adrenergic Receptor Signaling Pathway Response To Oxidative Stress Positive Regulation Of Synaptic Transmission, GABAergic Protein Oligomerization Cellular Cation Homeostasis Response To Radiation	Regulation Of Signaling Response To Stimulus Response To Organic Substance Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Response To Stress Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Positive Regulation Of Cellular Biosynthetic Process Cell Junction Assembly Regulation Of Cell Proliferation SMAD Protein Complex Assembly Negative Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Movement Signal Transduction Cellular Response To Organic Cyclic Compound Organ Development Anatomical Structure Morphogenesis Cellular Component Assembly Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Renal System Development Negative Regulation Of Signaling Regulation Of Cell Motility Gastrulation Cell-cell Signaling Regulation Of Cell Differentiation Negative Regulation Of Signal Transduction Regulation Of Locomotion Response To Wounding Urogenital System Development Regulation Of Cell Migration System Development Regulation Of Epithelial Cell Proliferation Adherens Junction Organization Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Positive Regulation Of Gene Expression Response To Organic Cyclic Compound Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		amplitude averaged bounded coefficients comparable components considerably deviation envelope exceeded fit intersubject intrasubject latency measurement measures middle mlr occasions oddball pa subject tended terms variability variation waveform waveforms waves	adoptive cd4 cholangiocarcinoma contained exists exomic experienced harnessed helper humans infiltrating interacting lymphocytes mediate metastatic mount mutated mutation polyfunctional prolonged pure recognizing regression retreated sequencing stabilization til transfer
Tagcloud (Difference) ?		amplitude averaged bounded coefficients comparable components considerably deviation envelope exceeded fit intersubject intrasubject latency measurement measures middle mlr occasions oddball pa subject tended terms variability variation waveform waveforms waves	adoptive cd4 cholangiocarcinoma contained exists exomic experienced harnessed helper humans infiltrating interacting lymphocytes mediate metastatic mount mutated mutation polyfunctional prolonged pure recognizing regression retreated sequencing stabilization til transfer
Tagcloud (Intersection) ?