GRB10 and RQCD1

Number of citations of the paper that reports this interaction (PMID 20878056)
2

Data Source:
BioGRID (pull down)

		GRB10	RQCD1
Gene Name		growth factor receptor-bound protein 10	RCD1 required for cell differentiation1 homolog (S. pombe)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Cytoplasmic MRNA Processing Body Nucleus Cytosol Membrane CCR4-NOT Complex
	Molecular Function	SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding	Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process	Insulin Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Insulin Negative Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Translation Sex Differentiation Gene Expression Cytokine-mediated Signaling Pathway Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
Pathways		Signaling by SCF-KIT Insulin receptor signalling cascade IRS activation Signal attenuation IRS-related events SHC-related events SHC activation Signaling by Insulin receptor	Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23512250) Bone mineral density ( 22504420) Fasting glucose-related traits (interaction with BMI) ( 22581228) Systemic sclerosis ( 21779181)
Protein-Protein Interactions		30 interactors: ABL1 AKT1 APP BCR DOK1 EGFR ELK1 EPHB1 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KDR KIT MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NOA1 PDGFRB RAF1 RET RQCD1 SRC ZDHHC17	6 interactors: AKT1 EGFR GIGYF1 GIGYF2 GRB10 MYB
Entrez ID		2887	9125
HPRD ID		03312	08828
Ensembl ID		ENSG00000106070	ENSG00000144580
Uniprot IDs		Q13322	B5MDQ4 B7Z1E5 D5MQE1 Q92600
PDB IDs		1NRV 3HK0	2FV2
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Cellular Component Movement Phosphorylation Cellular Response To Organic Substance Intracellular Signal Transduction Cellular Response To Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Migration ERBB Signaling Pathway Positive Regulation Of Cell Motility Peptidyl-amino Acid Modification Cellular Response To Organonitrogen Compound Positive Regulation Of Cellular Component Movement Signal Transduction Positive Regulation Of Locomotion Regulation Of Signaling Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Response To Organic Substance Signaling Regulation Of Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Neurotrophin TRK Receptor Signaling Pathway Cell Communication Cellular Response To Peptide Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Response To Hormone Regulation Of Cell Migration Fibroblast Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Fc Receptor Signaling Pathway	Insulin-like Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To UV-A Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Response To Epidermal Growth Factor Stimulus Mitotic Cell Cycle Response To Epidermal Growth Factor Homeostasis Of Number Of Cells Positive Regulation Of Vasoconstriction Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Glycogen Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Regulation Of Glycogen Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cell Cycle Process Regulation Of Vasoconstriction Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Glucose Import Cellular Response To Mechanical Stimulus Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Organonitrogen Compound Homeostatic Process Regulation Of Oxidoreductase Activity Embryonic Organ Development Gland Development In Utero Embryonic Development Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Surface Receptor Signaling Pathway Alkanesulfonate Metabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Glucose Transport Glial Cell Development Cellular Response To Hormone Stimulus Regulation Of Glucose Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Reactive Oxygen Species Metabolic Process Embryonic Placenta Development Cell Activation Response To UV Cellular Response To Stimulus Digestive Tract Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling
Tagcloud ?		becomes carries cytokine driven effector emerging exert fashion fos grbir homology hybrid insights interacting looked member nonreceptor obscure phosphorylated pleckstrin profoundly ptks subfamily subset suppresses syk tec tips turned
Tagcloud (Difference) ?		becomes carries cytokine driven effector emerging exert fashion fos grbir homology hybrid insights interacting looked member nonreceptor obscure phosphorylated pleckstrin profoundly ptks subfamily subset suppresses syk tec tips turned
Tagcloud (Intersection) ?