GPD1 and MDH1

Number of citations of the paper that reports this interaction (PMID 10190973)
1

Data Source:
HPRD (in vitro)

		GPD1	MDH1
Gene Name		glycerol-3-phosphate dehydrogenase 1 (soluble)	malate dehydrogenase 1, NAD (soluble)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Glycerol-3-phosphate Dehydrogenase Complex Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Mitochondrion Centrosome Cytosol Extracellular Vesicular Exosome
	Molecular Function	Glycerol-3-phosphate Dehydrogenase [NAD+] Activity Glycerol-3-phosphate Dehydrogenase Activity Protein Homodimerization Activity NAD Binding	Malic Enzyme Activity L-malate Dehydrogenase Activity Diiodophenylpyruvate Reductase Activity NAD Binding
	Biological Process	Gluconeogenesis NADH Oxidation Glycerophosphate Shuttle Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Triglyceride Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Glycolytic Process Glycerol-3-phosphate Catabolic Process Glycerophospholipid Biosynthetic Process Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADH Metabolic Process Pathogenesis Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process
Pathways		Synthesis of PA Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Phospholipid metabolism Glycerophospholipid biosynthesis Triglyceride Biosynthesis	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs		NADH	NADH Nicotinamide-Adenine-Dinucleotide 2\'-Monophosphoadenosine 5\'-Diphosphoribose
Diseases
GWAS
Protein-Protein Interactions		3 interactors: GK MDH1 PTN	7 interactors: EGFR FUS GPD1 MPP3 TERF1 TERF2IP TP53
Entrez ID		2819	4190
HPRD ID		00714	01100
Ensembl ID		ENSG00000167588	ENSG00000014641
Uniprot IDs		P21695	P40925
PDB IDs		1WPQ 1X0V 1X0X
Enriched GO Terms of Interacting Partners?		Glycerol-3-phosphate Biosynthetic Process Cellular Carbohydrate Metabolic Process Glycerol Catabolic Process Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Malate Metabolic Process Glycerol-3-phosphate Metabolic Process NADH Metabolic Process Oxaloacetate Metabolic Process Cellular Carbohydrate Catabolic Process Glycerol Metabolic Process Tricarboxylic Acid Cycle Organophosphate Metabolic Process Triglyceride Biosynthetic Process Carbohydrate Metabolic Process Citrate Metabolic Process Bone Mineralization NAD Metabolic Process Alcohol Catabolic Process Tricarboxylic Acid Metabolic Process Gluconeogenesis Aerobic Respiration Hexose Biosynthetic Process Biomineral Tissue Development Nicotinamide Nucleotide Metabolic Process Dicarboxylic Acid Metabolic Process Triglyceride Metabolic Process Neutral Lipid Metabolic Process Positive Regulation Of Cell Division Learning Glucose Metabolic Process Carbohydrate Biosynthetic Process Carbohydrate Catabolic Process	Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of DNA Replication Regulation Of Telomere Maintenance RNA-dependent DNA Replication Regulation Of Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cell Cycle Negative Regulation Of DNA Replication Cellular Response To Drug Regulation Of DNA Repair Regulation Of Mitotic Cell Cycle Cell Aging Negative Regulation Of Cell Cycle Telomere Maintenance Response To Osmotic Stress Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Chromosome Organization Alkanesulfonate Metabolic Process Glycerophosphate Shuttle Negative Regulation Of DNA Recombination At Telomere Nucleobase-containing Compound Metabolic Process Response To Drug Regulation Of Fibroblast Proliferation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Macromitophagy Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Oligodendrocyte Apoptotic Process Astrocyte Activation Regulation Of Response To DNA Damage Stimulus Response To UV Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Reactive Oxygen Species Metabolic Process Mitochondrial Transport Negative Regulation Of Helicase Activity Telomeric Loop Formation Age-dependent Telomere Shortening Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Mitotic Cell Cycle Circadian Rhythm Positive Regulation Of Protein Complex Assembly Telomere Maintenance Via Telomere Shortening
Tagcloud ?		abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pnpla2 pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Difference) ?		abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pnpla2 pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Intersection) ?