GNG5 and GNB5

Number of citations of the paper that reports this interaction (PMID 8636150)
15

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GNG5	GNB5
Gene Name		guanine nucleotide binding protein (G protein), gamma 5	guanine nucleotide binding protein (G protein), beta 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Vesicular Exosome	Nucleus Plasma Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity PDZ Domain Binding	GTPase Activity Signal Transducer Activity Protein Binding G-protein Gamma-subunit Binding Chaperone Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Signal Transduction Phototransduction, Visible Light Metabolic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding GPCR ligand binding Aquaporin-mediated transport beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: AMOTL2 EPS15L1 GNB1 GNB2 GNB3 GNB4 GNB5 GOLGA2 KRT31 KRT40 MDFI TRAF1	26 interactors: ANXA7 APP BNIP3L CDKN1A CSNK2B E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1
Entrez ID		2787	10681
HPRD ID		11865	09191
Ensembl ID		ENSG00000174021	ENSG00000069966
Uniprot IDs		P63218	B3KWS4 O14775
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Signal Transduction Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Rhodopsin Mediated Signaling Pathway Signaling Rhodopsin Mediated Signaling Pathway Cell Communication Cellular Response To Hormone Stimulus Cellular Response To Stimulus Response To Organonitrogen Compound Phototransduction, Visible Light Response To Hormone Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Negative Regulation Of Binding Detection Of Light Stimulus Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Response To Stimulus Cellular Response To Radiation Synaptic Transmission Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Oxidation-reduction Process Regulation Of Signal Transduction Regulation Of Binding Cellular Response To Prostaglandin E Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell-cell Signaling Cellular Response To Organic Substance Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Trophoblast Giant Cell Differentiation Regulation Of Signaling Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity	Cellular Response To Glucagon Stimulus Response To Glucagon Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Hormone Cellular Response To Stimulus Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Response To Stimulus Regulation Of Cellular Process Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organic Substance Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Response To Organonitrogen Compound G1/S Transition Of Mitotic Cell Cycle Synaptic Transmission Regulation Of Signaling Mitotic Cell Cycle Cellular Response To Light Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Regulation Of Metabolic Process Cell-cell Signaling Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Metabolic Process Response To Light Stimulus DNA Strand Elongation Involved In DNA Replication Cellular Process Cellular Response To Radiation Apoptotic Process DNA Strand Elongation Small Molecule Metabolic Process Rhodopsin Mediated Signaling Pathway
Tagcloud ?		adcy8 adcy9 br1 br2 consisted disturbance endometrial endometrium eventually fos g2 g3 gnb1 gng11 gng12 kinin kinins kras map2k2 mapk1 microarrays mitogenic oligonucleotide plcb4 prkacb prkar1a prkca reaching u133a
Tagcloud (Difference) ?		adcy8 adcy9 br1 br2 consisted disturbance endometrial endometrium eventually fos g2 g3 gnb1 gng11 gng12 kinin kinins kras map2k2 mapk1 microarrays mitogenic oligonucleotide plcb4 prkacb prkar1a prkca reaching u133a
Tagcloud (Intersection) ?