GNB3 and GNG12

Number of citations of the paper that reports this interaction (PMID 22940628)
1

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		GNB3	GNG12
Gene Name		guanine nucleotide binding protein (G protein), beta polypeptide 3	guanine nucleotide binding protein (G protein), gamma 12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Neuron Projection Cell Body Extracellular Vesicular Exosome	Heterotrimeric G-protein Complex Actin Filament Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding Spectrin Binding GTPase Binding	Signal Transducer Activity PDZ Domain Binding Phosphate Ion Binding
	Biological Process	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Regulation Of Blood Pressure Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Cerebral Cortex Development Response To Lipopolysaccharide Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Peptide hormone metabolism Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Incretin synthesis, secretion, and inactivation Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS		Response to Vitamin E supplementation ( 22437554)
Protein-Protein Interactions		11 interactors: GNG10 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 RASD2 TGFBR1	6 interactors: CAPN1 FHL2 GNB1 GNB2 GNB3 GNB4
Entrez ID		2784	55970
HPRD ID		00743	13592
Ensembl ID		ENSG00000111664	ENSG00000172380
Uniprot IDs		E9PCP0 F1T0G5 P16520	Q9UBI6
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hormone Stimulus Synaptic Transmission Response To Organonitrogen Compound Cell-cell Signaling Response To Hormone G-protein Coupled Receptor Signaling Pathway Cellular Response To Organic Substance Oxidation-reduction Process Response To Organic Substance Cell Surface Receptor Signaling Pathway Small Molecule Metabolic Process Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Protein Kinase B Signaling Cellular Metabolic Process Regulation Of Protein Kinase B Signaling Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Protein Ubiquitination Parathyroid Gland Development Receptor Guanylyl Cyclase Signaling Pathway Locomotory Behavior Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Endothelial Cell Activation Response To Lipid Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Sumoylation Cellular Response To Prostaglandin E Stimulus Synaptic Transmission, Dopaminergic Positive Regulation Of SMAD Protein Import Into Nucleus Activation Of Protein Kinase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of SMAD Protein Import Into Nucleus Regulation Of Signaling	Cellular Response To Glucagon Stimulus Response To Glucagon Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Hormone Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Small Molecule Metabolic Process Response To Organic Substance Oxidation-reduction Process Synaptic Transmission Cellular Response To Organic Substance Atrial Cardiac Muscle Cell Development Cell-cell Signaling Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process G-protein Coupled Receptor Signaling Pathway Signal Transduction Receptor Catabolic Process Cellular Response To Prostaglandin E Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell Communication Heart Trabecula Formation Ventricular Cardiac Muscle Cell Development Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Cellular Metabolic Process Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Catecholamine Stimulus Heart Trabecula Morphogenesis Ventricular Cardiac Muscle Cell Differentiation Cellular Response To Stimulus Rhodopsin Mediated Signaling Pathway Dopamine Receptor Signaling Pathway Substantia Nigra Development Androgen Receptor Signaling Pathway Cellular Response To Fatty Acid Trabecula Morphogenesis Neural Nucleus Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
Tagcloud ?		allele alleles black bmi differed excessive fto gained gestational greatest gwg homozygote homozygous income infant m2 modifiable noncarriers nonobese nonrisk obese observational postpartum pounds predisposes pregnant prepregnancy tt weights	adcy8 adcy9 br1 br2 consisted disturbance endometrial endometrium eventually fos g2 g3 gnb1 gng11 gng5 kinin kinins kras map2k2 mapk1 microarrays mitogenic oligonucleotide plcb4 prkacb prkar1a prkca reaching u133a
Tagcloud (Difference) ?		allele alleles black bmi differed excessive fto gained gestational greatest gwg homozygote homozygous income infant m2 modifiable noncarriers nonobese nonrisk obese observational postpartum pounds predisposes pregnant prepregnancy tt weights	adcy8 adcy9 br1 br2 consisted disturbance endometrial endometrium eventually fos g2 g3 gnb1 gng11 gng5 kinin kinins kras map2k2 mapk1 microarrays mitogenic oligonucleotide plcb4 prkacb prkar1a prkca reaching u133a
Tagcloud (Intersection) ?