GNA12 and CDH15

Number of citations of the paper that reports this interaction (PMID 11136230)
34

Data Source:
HPRD (two hybrid, in vitro)

		GNA12	CDH15
Gene Name		guanine nucleotide binding protein (G protein) alpha 12	cadherin 15, type 1, M-cadherin (myotubule)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Brush Border Membrane	Plasma Membrane Caveola Integral Component Of Membrane Neuromuscular Junction Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding	Calcium Ion Binding
	Biological Process	In Utero Embryonic Development G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Drug Embryonic Digit Morphogenesis	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Junction Assembly Adherens Junction Organization Muscle Cell Differentiation Cell-cell Junction Organization Positive Regulation Of Muscle Cell Differentiation
Pathways		Thrombin signalling through proteinase activated receptors (PARs) Signaling by GPCR GPCR downstream signaling G alpha (12/13) signalling events Platelet activation, signaling and aggregation	Cell junction organization Cell-cell junction organization CDO in myogenesis Myogenesis Adherens junctions interactions
Drugs
Diseases
GWAS		Height ( 20881960 19343178 18391951 20189936) Ulcerative colitis ( 23128233 21297633) White matter integrity ( 23218918)
Protein-Protein Interactions		30 interactors: ACTB AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 RHOA S1PR4 S1PR5 TBXA2R TEC TSHR	10 interactors: ARVCF BOC CDH7 CDH9 CDON CTNNA1 CTNNB1 GNA12 JUP SGTA
Entrez ID		2768	1013
HPRD ID		05093	00225
Ensembl ID		ENSG00000146535	ENSG00000129910
Uniprot IDs		B3KXS2 E9PC54 Q03113 Q6ZQV4	P55291
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Cell Surface Receptor Signaling Pathway Signaling Cell Communication Signal Transduction Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To Wounding Cellular Response To Stimulus Cellular Calcium Ion Homeostasis Blood Coagulation Regulation Of Body Fluid Levels Calcium Ion Homeostasis Hemostasis Response To Organic Substance Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cellular Metal Ion Homeostasis Apoptotic Process Programmed Cell Death Cellular Cation Homeostasis Cellular Ion Homeostasis Cell Death Death Metal Ion Homeostasis Regulation Of Signaling Chemical Homeostasis Response To Stimulus Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Homeostatic Process Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Cellular Homeostasis Neurotrophin TRK Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Metabolic Process Response To External Stimulus Neurotrophin Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Phospholipase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway	Adherens Junction Organization Cellular Response To Indole-3-methanol Cell Adhesion Cell Junction Assembly Cell-cell Junction Organization Single Organismal Cell-cell Adhesion Positive Regulation Of Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Regulation Of Neural Precursor Cell Proliferation Muscle Cell Differentiation Protein Heterooligomerization Epithelial Cell-cell Adhesion Regulation Of Cell Fate Specification Muscle Structure Development Regulation Of Cell Fate Commitment Regulation Of Neuroblast Proliferation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Adherens Junction Assembly Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Embryonic Digit Morphogenesis Cellular Response To Organic Cyclic Compound Cellular Component Assembly Protein Oligomerization Odontogenesis Of Dentin-containing Tooth Cell Fate Specification Cell Surface Receptor Signaling Pathway Lens Development In Camera-type Eye Regulation Of Stem Cell Proliferation Cell-cell Junction Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Multicellular Organismal Development Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Integrin-mediated Signaling Pathway Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Smoothened Signaling Pathway Odontogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Camera-type Eye Morphogenesis Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development
Tagcloud ?		anticipate arena atg16l1 card9 colitis crohn culminating forwards furthered gwa hnf4a ibds icoslg il10 il12b il1r2 il23 il23r irgm lamb1 nkx2 ormdl3 outlined paralleling prdm1 revolutionised successes theme ulcerative
Tagcloud (Difference) ?		anticipate arena atg16l1 card9 colitis crohn culminating forwards furthered gwa hnf4a ibds icoslg il10 il12b il1r2 il23 il23r irgm lamb1 nkx2 ormdl3 outlined paralleling prdm1 revolutionised successes theme ulcerative
Tagcloud (Intersection) ?