NPHP3 and NPHP1

Number of citations of the paper that reports this interaction (PMID 12872122)
69

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		NPHP3	NPHP1
Gene Name		nephronophthisis 3 (adolescent)	nephronophthisis 1 (juvenile)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cilium Primary Cilium	Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Tight Junction Membrane Motile Cilium Photoreceptor Connecting Cilium Ciliary Transition Zone Ciliary Base
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Kidney Development Heart Looping Atrial Septum Development Organelle Organization Determination Of Left/right Symmetry Wnt Signaling Pathway Lung Development Determination Of Pancreatic Left/right Asymmetry Photoreceptor Cell Maintenance Maintenance Of Organ Identity Convergent Extension Involved In Gastrulation Cilium Morphogenesis Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Kidney Morphogenesis Determination Of Intestine Left/right Asymmetry Determination Of Stomach Left/right Asymmetry Determination Of Liver Left/right Asymmetry Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure	Organelle Organization Signal Transduction Excretion Visual Behavior Single Organismal Cell-cell Adhesion Cell Projection Organization Actin Cytoskeleton Organization Cellular Protein Localization Photoreceptor Cell Outer Segment Organization Spermatid Differentiation Retina Development In Camera-type Eye
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Trafficking of myristoylated proteins to the cilium Assembly of the primary cilium	Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Menarche (age at onset) ( 21102462)
Protein-Protein Interactions		2 interactors: ATXN1 NPHP1	15 interactors: ADAM15 ARHGAP32 BCAR1 FLNA FLNB FLNC INVS KHDRBS1 NPHP3 NPHP4 PAK2 PTK2B TNK2 TUBB UBQLN4
Entrez ID		27031	4867
HPRD ID		06417	09524
Ensembl ID		ENSG00000113971	ENSG00000144061
Uniprot IDs		Q7Z494	B4DQY0 C9JNM7 O15259
PDB IDs			1S1N
Enriched GO Terms of Interacting Partners?		Visual Behavior Response To Light Stimulus Response To Radiation Single-organism Behavior Photoreceptor Cell Outer Segment Organization Behavior Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Abiotic Stimulus	Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Movement Of Cell Or Subcellular Component Actin Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament-based Process Cytoskeleton Organization Cellular Response To Stimulus Response To Stimulus Integrin-mediated Signaling Pathway Innate Immune Response Regulation Of Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Tissue Homeostasis Photoreceptor Cell Maintenance Regulation Of Signaling Negative Regulation Of Wnt Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cell Junction Assembly Protein Autophosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Developmental Process Multicellular Organismal Homeostasis Tissue Development Cell Differentiation Regulation Of Growth Cell Projection Organization Cell Development Positive Regulation Of Endothelial Cell Migration Epithelial To Mesenchymal Transition Cell Adhesion Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Retina Homeostasis Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Locomotion Regulation Of Wnt Signaling Pathway Actin Filament Organization Immune Response Positive Regulation Of Translation Anatomical Structure Development Mitotic Cell Cycle Defense Response Positive Regulation Of Epithelial Cell Migration Regulation Of Cell Growth
Tagcloud ?		3q21 adolescent amaurosis autosomal boundaries cha cystic descent exons haplotypes homozygosity indicative intron kiaa0678 leber loken mapped mutational nephronophthisis nph3 perones q22 recessive senior sequenced sls sls3 slsn3	ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cep76 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nephronophthisis nphp4 rpgrip1 rpgrip1l tgl throw ttl
Tagcloud (Difference) ?		3q21 adolescent amaurosis autosomal boundaries cha cystic descent exons haplotypes homozygosity indicative intron kiaa0678 leber loken mapped mutational nph3 perones q22 recessive senior sequenced sls sls3 slsn3	ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cep76 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nphp4 rpgrip1 rpgrip1l tgl throw ttl
Tagcloud (Intersection) ?		nephronophthisis