AMH and PCSK5

Number of citations of the paper that reports this interaction (PMID 8755541)
11

Data Source:
HPRD (in vivo, in vitro)

		AMH	PCSK5
Gene Name		anti-Mullerian hormone	proprotein convertase subtilisin/kexin type 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Space Golgi Apparatus Golgi Lumen Integral Component Of Membrane Secretory Granule
	Molecular Function	Receptor Binding Transforming Growth Factor Beta Receptor Binding Hormone Activity Growth Factor Activity	Serine-type Endopeptidase Activity Peptidase Activity Peptide Binding
	Biological Process	Preantral Ovarian Follicle Growth Urogenital System Development Mullerian Duct Regression Cell-cell Signaling Gonadal Mesoderm Development Sex Determination Sex Differentiation Aging Positive Regulation Of Gene Expression Response To Organic Cyclic Compound Response To Drug Positive Regulation Of NF-kappaB Transcription Factor Activity	Kidney Development Renin Secretion Into Blood Stream Signal Peptide Processing Proteolysis Cell-cell Signaling Heart Development Embryo Implantation Anterior/posterior Pattern Specification Protein Processing Peptide Hormone Processing Viral Life Cycle Respiratory Tube Development Nerve Growth Factor Processing Limb Morphogenesis Cytokine Biosynthetic Process Peptide Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Embryonic Digestive Tract Development Embryonic Skeletal System Development
Pathways			Signalling by NGF NGF processing
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (age of onset) ( 22959728) Height ( 20881960 23563607) Metabolite levels (5-HIAA) ( 23319000) Response to fenofibrate (adiponectin levels) ( 23149075) Total ventricular volume ( 21116278)
Protein-Protein Interactions		6 interactors: AMHR2 ARL8B EGFR ETV5 PCSK5 ZMAT2	20 interactors: AMH APPBP2 ATN1 CACNA1A GLRX3 HOXA1 ITGA6 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP4-12 KRTAP5-9 LCE3C MEOX2 NOTCH2NL NUFIP2 PMCH PTPRM REN STK16
Entrez ID		268	5125
HPRD ID		02979	08985
Ensembl ID		ENSG00000104899	ENSG00000099139
Uniprot IDs		P03971	Q92824
PDB IDs
Enriched GO Terms of Interacting Partners?		Single Organism Reproductive Process Reproductive Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Alkanesulfonate Metabolic Process Anti-Mullerian Hormone Signaling Pathway Negative Regulation Of Anti-Mullerian Hormone Signaling Pathway Renin Secretion Into Blood Stream Developmental Process Involved In Reproduction Digestive Tract Development Digestive System Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Enzyme Linked Receptor Protein Signaling Pathway Signaling Activation Of Phospholipase A2 Activity Nerve Growth Factor Processing Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase A2 Activity Male Germ-line Stem Cell Asymmetric Division Respiratory Tube Development Response To Cobalamin Response To UV-A Response To Hydroxyisoflavone Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Signal Transduction By Phosphorylation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Skeletal Muscle Acetylcholine-gated Channel Clustering Mullerian Duct Regression Cellular Response To Stimulus Positive Regulation Of Catenin Import Into Nucleus Protein Localization To Membrane Regulation Of Phospholipase A2 Activity Positive Regulation Of Glial Cell Proliferation Regulation Of Superoxide Anion Generation Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Response To Oxidative Stress Cell Division Magnesium Ion Homeostasis Anatomical Structure Regression Embryonic Organ Development Signal Peptide Processing Cellular Response To Estradiol Stimulus Intracellular Signal Transduction Cellular Response To Organic Substance Protein Insertion Into Membrane	Developmental Process Multicellular Organismal Development Pons Development Cell Differentiation Anatomical Structure Development Organ Development System Development Tissue Development Behavior Neural Nucleus Development Optokinetic Behavior Cerebellar Molecular Layer Development Abducens Nerve Formation Neuron Death Vestibular Nucleus Development Facial Nucleus Development Preantral Ovarian Follicle Growth Urogenital System Development Feeding Behavior Positive Regulation Of Gene Expression Rhombomere 4 Development Cerebellum Maturation Semicircular Canal Formation Musculoskeletal Movement, Spinal Reflex Action Anatomical Structure Morphogenesis Rhombomere 3 Development Rhombomere 5 Development Gamma-aminobutyric Acid Secretion Renin-angiotensin Regulation Of Aldosterone Production Metencephalon Development Neuromuscular Process Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Response To Drug Rhythmic Synaptic Transmission Somite Specification Ectodermal Cell Differentiation Cell Development Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Oogenesis Stage Cell Projection Organization Drinking Behavior Gonadal Mesoderm Development Response To CGMP Mullerian Duct Regression Hindbrain Development Cell Morphogenesis Involved In Neuron Differentiation Calcium Ion-dependent Exocytosis Of Neurotransmitter
Tagcloud ?		abp adluminal androgens basement biochemically ceruloplasmin corroboration cu2 deliver epididymis fe3 ferric germinal historical huggenvik inhibin lactalbumin laminin move nutritive secrete secretions seminiferous sertoli sgp somatomedin stated synthesize transferrin	angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1
Tagcloud (Difference) ?		abp adluminal androgens basement biochemically ceruloplasmin corroboration cu2 deliver epididymis fe3 ferric germinal historical huggenvik inhibin lactalbumin laminin move nutritive secrete secretions seminiferous sertoli sgp somatomedin stated synthesize transferrin	angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1
Tagcloud (Intersection) ?