GDF2 and BMPR2

Number of citations of the paper that reports this interaction (PMID 22718755)
11

Data Source:
BioGRID (pull down)

		GDF2	BMPR2
Gene Name		growth differentiation factor 2	bone morphogenetic protein receptor, type II (serine/threonine kinase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Basal Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Neuronal Cell Body Spanning Component Of Plasma Membrane
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity	Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Metal Ion Binding
	Biological Process	Ossification Angiogenesis Patterning Of Blood Vessels Vasculogenesis Osteoblast Differentiation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Cellular Iron Ion Homeostasis Negative Regulation Of DNA Replication Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Interleukin-8 Production Activin Receptor Signaling Pathway Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Development Blood Vessel Morphogenesis Cartilage Development Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Cellular Response To BMP Stimulus Negative Regulation Of DNA Biosynthetic Process	Mesoderm Formation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Vasoconstriction Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of DNA Biosynthetic Process
Pathways			Signaling by BMP
Drugs
Diseases
GWAS			Urate levels ( 23263486)
Protein-Protein Interactions		3 interactors: ACVR2A ACVR2B BMPR2	49 interactors: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1
Entrez ID		2658	659
HPRD ID		05492	02880
Ensembl ID		ENSG00000128802	ENSG00000204217
Uniprot IDs		Q9UK05	Q13873
PDB IDs		1ZKZ 4FAO	2HLQ 3G2F
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Mesoderm Development Positive Regulation Of Activin Receptor Signaling Pathway Lymphatic Endothelial Cell Differentiation Gastrulation Regulation Of Ossification Lymphangiogenesis Lymph Vessel Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Venous Blood Vessel Development Signal Transduction By Phosphorylation Retina Vasculature Development In Camera-type Eye Regulation Of Activin Receptor Signaling Pathway Lymph Vessel Development Pattern Specification Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Blood Vessel Remodeling Skeletal System Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Gastrulation With Mouth Forming Second Embryonic Morphogenesis Artery Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Differentiation Regulation Of BMP Signaling Pathway Endothelium Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Determination Of Left/right Symmetry Tissue Remodeling Determination Of Bilateral Symmetry Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Embryo Development Positive Regulation Of Protein Metabolic Process Retina Development In Camera-type Eye Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Lung Blood Pressure	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ossification Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Cell Development Regulation Of Bone Mineralization Regulation Of MAPK Cascade Regulation Of Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Cell Differentiation Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorus Metabolic Process Growth Signal Transduction By Phosphorylation Regulation Of Signal Transduction Cartilage Development Regulation Of Ossification Positive Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cartilage Development Regulation Of Growth Cell Surface Receptor Signaling Pathway Connective Tissue Development Positive Regulation Of Cartilage Development Phosphate-containing Compound Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Response To Stimulus
Tagcloud ?			apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Difference) ?			apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Intersection) ?