GC and CDC73

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GC	CDC73
Gene Name		group-specific component (vitamin D binding protein)	cell division cycle 73
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Lysosomal Lumen Extracellular Vesicular Exosome Blood Microparticle	Nucleus Nucleoplasm Cdc73/Paf1 Complex
	Molecular Function	Actin Binding Vitamin D Binding Vitamin Transporter Activity Calcidiol Binding	RNA Polymerase II Core Binding Protein Binding
	Biological Process	Steroid Metabolic Process Vitamin D Metabolic Process Small Molecule Metabolic Process Vitamin Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Proliferation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Metabolism of lipids and lipoproteins Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Hedgehog Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Metabolite levels ( 22916037) Non-alcoholic fatty liver disease histology (other) ( 23213074) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 22673963 20418485)	Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		12 interactors: ACTA1 ACTA2 ACTC1 C3 CCND3 CDC73 CUBN GRB2 LRIF1 LRP2 PIK3R3 SERF2	30 interactors: ALAS1 ANXA6 CCDC155 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 HAP1 HIST1H1C HSF2BP HSPA4 ITFG1 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 PITHD1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TSGA10 VPS37B WWC1
Entrez ID		2638	79577
HPRD ID		00749	09581
Ensembl ID		ENSG00000145321	ENSG00000134371
Uniprot IDs		P02774	Q6P1J9
PDB IDs		1J78 1J7E 1KW2 1KXP 1LOT 1MA9
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Vitamin D Metabolic Process Actin-myosin Filament Sliding Muscle Filament Sliding Muscle Contraction Actin-mediated Cell Contraction Muscle System Process Actin Filament-based Movement Receptor-mediated Endocytosis Myofibril Assembly Tissue Development Skeletal Muscle Fiber Adaptation Positive Regulation Of Type IIa Hypersensitivity Cell Development Response To External Stimulus Anatomical Structure Formation Involved In Morphogenesis Actomyosin Structure Organization Vitamin Metabolic Process Positive Regulation Of Activation Of Membrane Attack Complex Insulin Receptor Signaling Pathway Striated Muscle Cell Development Lipid Metabolic Process Glomerular Mesangial Cell Development Regulation Of Phosphorylation Muscle Cell Development Cobalamin Transport Mesangial Cell Development Positive Regulation Of Hypersensitivity Endocytosis Renal Interstitial Fibroblast Development Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Histone H2B Ubiquitination Skeletal Muscle Adaptation Response To Stimulus Regulation Of Phosphorus Metabolic Process Cellular Response To Insulin Stimulus	Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Histone H2B Ubiquitination Cellular Localization Positive Regulation Of Glycoprotein Biosynthetic Process Establishment Of Localization In Cell Genitalia Morphogenesis Positive Regulation Of Glycoprotein Metabolic Process Organelle Organization Histone Monoubiquitination Regulation Of Glycoprotein Biosynthetic Process Establishment Of Protein Localization To Organelle Protein Localization Chromosome Organization Histone Ubiquitination Protein Import Positive Regulation Of Epithelial To Mesenchymal Transition Cellular Process Cytoplasmic Transport Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Methylation Intracellular Transport Positive Regulation Of Neurogenesis Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Organ Growth Organelle Localization Transcription-coupled Nucleotide-excision Repair Regulation Of Oligodendrocyte Differentiation Protein Targeting Protein Monoubiquitination Myoblast Differentiation Regulation Of Intracellular Transport Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation Of Potassium Ion Export Regulation Of Myelination Positive Regulation Of Intracellular Signal Transduction Skin Morphogenesis Vesicle Localization Regulation Of Histone Methylation Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Development Genitalia Development Regulation Of Intracellular Signal Transduction Skin Development Regulation Of Epithelial To Mesenchymal Transition Protein Localization To Organelle Protein Transmembrane Transport
Tagcloud ?		absent agglutinin bcr bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55	1379delt affecting caucasian encoded fibroma hpt hyperparathyroidism hystologically instrumental jaw jt l460lfs mandible modelling moiety mtt ossifying parafibromin parathyroid partners proband pth relatives sanger sca silico terminus underlie vast
Tagcloud (Difference) ?		absent agglutinin bcr bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55	1379delt affecting caucasian encoded fibroma hpt hyperparathyroidism hystologically instrumental jaw jt l460lfs mandible modelling moiety mtt ossifying parafibromin parathyroid partners proband pth relatives sanger sca silico terminus underlie vast
Tagcloud (Intersection) ?